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MMP15 Knockout Cell Lines

Gene: MMP15

Official Full Name: matrix metallopeptidase 15provided by HGNC

Gene Summary: This gene encodes a member of the peptidase M10 family and membrane-type subfamily of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Members of this subfamily contain a transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. The encoded preproprotein is proteolytically processed to generate the mature protease. This protein may play a role in cancer progression. [provided by RefSeq, Jan 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO36608 MMP15 Knockout cell line (HeLa) Human MMP15 1:3~1:6 Negative Online Inquiry
KO36609 MMP15 Knockout cell line (HCT 116) Human MMP15 1:2~1:4 Negative Online Inquiry
KO36610 MMP15 Knockout cell line (HEK293) Human MMP15 1:3~1:6 Negative Online Inquiry
KO36611 MMP15 Knockout cell line (A549) Human MMP15 1:3~1:4 Negative Online Inquiry

Background

MMP15 Gene Knockout Cell Lines are specialized cellular models engineered to lack the Matrix Metalloproteinase 15 (MMP15) gene, essential in the context of extracellular matrix remodeling and cellular behavior. These knockout cell lines provide an invaluable tool for dissecting the precise roles of MMP15 in various biological processes, such as tissue repair, inflammation, and cancer metastasis.

The primary mechanism of action revolves around the absence of MMP15, which is known to facilitate the degradation of extracellular matrix components, thereby influencing cellular migration and invasion. By employing these knockout lines in research, scientists can elucidate the contributions of MMP15 to pathological conditions and the molecular signaling pathways involved in development and disease.

The scientific importance of MMP15 Gene Knockout Cell Lines extends to diverse fields, including oncology, regenerative medicine, and developmental biology. Their application facilitates high-throughput screening of therapeutic compounds targeting MMP15-associated pathways, allowing for more accurate modeling of disease states and the identification of novel pharmacological targets.

Compared to other genetic models, MMP15 knockout cell lines offer a unique advantage due to their specificity and reproducibility, reducing variability in experimental outcomes. As a result, researchers and clinicians can obtain more consistent results, leading to more reliable data for hypothesis testing and therapeutic discovery.

This product is particularly valuable for research laboratories focusing on matrix biology and related fields, providing a more precise understanding of MMP15's role in health and disease. The use of MMP15 Gene Knockout Cell Lines enables significant advancements in the development of targeted therapies.

With a robust portfolio of advanced biological reagents and models, our company stands at the forefront of cutting-edge research solutions, dedicated to empowering scientists and clinicians in their pursuit of groundbreaking discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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