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MMP14 Knockout Cell Lines

Gene: MMP14

Official Full Name: matrix metallopeptidase 14provided by HGNC

Gene Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00533 MMP14 Knockout cell line (HCT 116) Human MMP14 1:2~1:4 Negative Online Inquiry
KO08320 MMP14 Knockout cell line (HeLa) Human MMP14 1:3~1:6 Negative Online Inquiry
KO08321 MMP14 Knockout cell line (A549) Human MMP14 1:3~1:4 Negative Online Inquiry

Background

MMP14 Gene Knockout Cell Lines are engineered cellular models that possess a specific disruption of the matrix metalloproteinase 14 (MMP14) gene, crucial for understanding the physiological and pathological roles of this enzyme in various biological contexts. MMP14 is known for its involvement in the extracellular matrix remodeling process and plays a significant role in tissue repair, cancer metastasis, and angiogenesis. The knockout of the MMP14 gene provides a valuable tool for elucidating these mechanisms by allowing researchers to study the effects of its absence on cellular behavior, signaling pathways, and overall cellular function.

These cell lines enable scientists to explore key functions of MMP14, such as its role in the activation of other metalloproteinases and involvement in cell migration, invasion, and proliferation. By studying MMP14 knockout cells, researchers can tease apart the intricate networks of cellular signaling involved in tissue homeostasis and disease processes, providing insights that are crucial for developing targeted therapies and innovative treatment modalities.

The importance of MMP14 Gene Knockout Cell Lines in research and clinical applications cannot be overstated. They provide a platform for drug discovery, cancer biology studies, and regenerative medicine, making them indispensable for both academic and pharmaceutical research environments. Compared to conventional cell lines, the specific knockout of MMP14 provides a more accurate model for studying the related pathophysiological conditions, ultimately leading to better experimental reproducibility and reliability in results.

Offering a unique combination of precision and versatility, MMP14 Gene Knockout Cell Lines stand out in their ability to address questions that are difficult to resolve with wild-type cell lines, making them an essential resource for advancing scientific knowledge. With our expertise in developing high-quality biological products, we are committed to supporting researchers and clinicians with the tools they need to push the boundaries of discovery and innovation in their respective fields.

Please note that all services are for research use only. Not intended for any clinical use.

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