Home / MME Knockout Cell Lines

MME Knockout Cell Lines

Gene: MME

Official Full Name: membrane metalloendopeptidaseprovided by HGNC

Gene Summary: The protein encoded by this gene is a type II transmembrane glycoprotein and a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). The encoded protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. [provided by RefSeq, Aug 2017]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO09893 MME Knockout cell line (HEK293) Human MME 1:3~1:6 Negative Online Inquiry

Background

MME Gene Knockout Cell Lines are specially engineered cellular models that have had the membrane metalloendopeptidase (MME) gene selectively inactivated through precise CRISPR-Cas9 genome editing techniques. These sophisticated cell lines provide researchers with a robust platform to study the physiological and pathological roles of MME, which is implicated in various biological processes, including neuropeptide metabolism and cardiovascular functioning. By facilitating the elimination of MME, these knockout models enable clear assessment of the gene's specific contributions, thereby shedding light on intrinsic cellular mechanisms and interactions.

The key function of MME Gene Knockout Cell Lines lies in their unique ability to elucidate the consequences of MME suppression. By creating this cellular context, researchers can explore the effects of MME knockout on cellular signaling pathways, tissue homeostasis, and disease onset models, particularly in neurodegenerative and cardiovascular diseases. This precise manipulation opens up numerous avenues for investigation and potential therapeutic strategies.

The scientific importance of these cell lines is profound, as they have applications in both basic research and translational contexts. In a research setting, they serve as vital tools for drug discovery and validation of molecular targets, while in clinical settings, they hold promise for developing targeted therapies and personalized medicine. Moreover, with increasing interest in gene therapy, MME Gene Knockout Cell Lines are poised to become indispensable assets in pharmacogenomics and other cutting-edge biotechnologies.

What sets our MME Gene Knockout Cell Lines apart from alternatives is their high specificity and the minimal off-target effects achieved through our advanced editing techniques. Each line is thoroughly validated to ensure reproducibility and reliability in experimental outcomes, providing researchers with confidence in their findings.

For researchers and clinicians alike, these gene knockout models offer unmatched value by providing clearer insights into gene function and enabling innovative therapeutic explorations. Our commitment to quality and cutting-edge methodologies underscores our expertise in biological products, ensuring that our customers receive only the best tools to advance their research objectives.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.