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MMADHC Knockout Cell Lines

Gene: MMADHC

Official Full Name: metabolism of cobalamin associated Dprovided by HGNC

Gene Summary: This gene encodes a mitochondrial protein that is involved in an early step of vitamin B12 metabolism. Vitamin B12 (cobalamin) is essential for normal development and survival in humans. Mutations in this gene cause methylmalonic aciduria and homocystinuria type cblD (MMADHC), a disorder of cobalamin metabolism that is characterized by decreased levels of the coenzymes adenosylcobalamin and methylcobalamin. Pseudogenes have been identified on chromosomes 11 and X.[provided by RefSeq, Nov 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO27704 MMADHC Knockout cell line (HeLa) Human MMADHC 1:3~1:6 Negative Online Inquiry
KO27705 MMADHC Knockout cell line (HCT 116) Human MMADHC 1:2~1:4 Negative Online Inquiry
KO27706 MMADHC Knockout cell line (HEK293) Human MMADHC 1:3~1:6 Negative Online Inquiry
KO27707 MMADHC Knockout cell line (A549) Human MMADHC 1:3~1:4 Negative Online Inquiry

Background

MMADHC Gene Knockout Cell Lines are specifically engineered cellular models designed to facilitate the investigation of the roles and functions of the MMADHC gene, a critical component involved in mitochondrial metabolism and cellular bioenergetics. These knockout cell lines are generated through advanced CRISPR-Cas9 gene-editing technology, which ensures precise deletion of the MMADHC gene, allowing researchers to study its specific contributions to cellular physiology and disease processes.

The key function of these knockout cell lines lies in their ability to provide insights into mitochondrial dysfunction linked to various pathophysiological conditions, such as metabolic disorders and neurodegenerative diseases. By eliminating the MMADHC gene, these cell lines enable researchers to observe altered metabolic pathways, assess changes in cellular respiration, and evaluate how these alterations impact overall cellular health and viability.

In terms of scientific importance, MMADHC Gene Knockout Cell Lines serve as invaluable tools in both basic and applied research settings, including drug development and toxicity screening. They can facilitate high-throughput screening of potential therapeutics aimed at combating mitochondrial diseases, as well as help elucidate the molecular mechanisms underlying metabolic pathways.

What sets these knockout cell lines apart from traditional models is their enhanced specificity and accuracy, allowing for more reliable data interpretation. Unlike non-targeted methods, like chemical inhibition, the genetic approach eliminates off-target effects and provides a clearer understanding of gene function.

For researchers and clinicians, the ability to access robust and versatile models of gene knockout enhances research productivity, accelerates the development of innovative therapies, and ultimately contributes to improved patient outcomes. Moreover, the utility of these cell lines in translational research coupled with their easy adaptability make them essential components in modern biological studies.

As a leader in genetic engineering and biotechnology, our company remains committed to delivering high-quality research tools like the MMADHC Gene Knockout Cell Lines, backed by years of expertise in cell culture and molecular biology, ensuring that researchers have access to cutting-edge resources that drive scientific excellence.

Please note that all services are for research use only. Not intended for any clinical use.

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