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MKNK1 Knockout Cell Lines

Gene: MKNK1

Official Full Name: MAPK interacting serine/threonine kinase 1provided by HGNC

Gene Summary: This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO08298 MKNK1 Knockout cell line (HeLa) Human MKNK1 1:3~1:6 Negative Online Inquiry
KO08299 MKNK1 Knockout cell line (HCT 116) Human MKNK1 1:2~1:4 Negative Online Inquiry
KO08300 MKNK1 Knockout cell line (HEK293) Human MKNK1 1:3~1:6 Negative Online Inquiry
KO08301 MKNK1 Knockout cell line (A549) Human MKNK1 1:3~1:4 Negative Online Inquiry

Background

MKNK1 Gene Knockout Cell Lines are innovative biological tools designed for investigating the functional roles of the MKNK1 gene within various cellular processes. Through a targeted gene editing approach, these cell lines are engineered to lack the MKNK1 gene, allowing researchers to elucidate its contributions to signaling pathways, stress responses, and overall cellular homeostasis.

Key functions of the MKNK1 gene revolve around its role in regulating translation and responding to extracellular signals, particularly in the context of MAPK signaling pathways. By utilizing these knockout cell lines, scientists can dissect the molecular mechanisms at play in key biological processes such as cell proliferation, apoptosis, and differentiation. The absence of MKNK1 serves as a powerful tool for examining the compensatory pathways that cells adopt and identifying potential therapeutic targets for diseases like cancer, where dysregulation of translation is often observed.

The scientific value of MKNK1 Gene Knockout Cell Lines in both research and clinical applications cannot be overstated. These lines facilitate insights into how the loss of MKNK1 alters cellular behavior, thus supporting drug development efforts and advancing our understanding of oncogenic processes. They can be utilized in various experiments, ranging from mechanistic studies to high-throughput screening, making them versatile assets in any molecular biology laboratory.

Compared to alternative methods of gene silencing, such as RNA interference, MKNK1 knockout cell lines offer the significant advantage of complete and stable gene disruption. This results in more definitive results and easier reproducibility across experiments, providing researchers with a reliable platform to establish causal relationships between MKNK1 and various biological outcomes.

Furthermore, the inherent value of this product lies in its ability to empower researchers and clinicians with deeper insights into gene function and cellular dynamics, ultimately aiding in the development of more effective therapeutic interventions.

As experts in advanced genetic engineering, our company is committed to delivering high-quality biological products that support cutting-edge research. We stand behind our MKNK1 Gene Knockout Cell Lines, ensuring they undergo rigorous validation to meet the highest standards of reliability and efficacy for our clients.

Please note that all services are for research use only. Not intended for any clinical use.

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