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MICU3 Knockout Cell Lines

Gene: MICU3

Official Full Name: mitochondrial calcium uptake family member 3provided by HGNC

Gene Summary: Enables calcium channel regulator activity; calcium ion sensor activity; and protein heterodimerization activity. Involved in calcium import into the mitochondrion and cellular response to calcium ion. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO16173 MICU3 Knockout cell line (HEK293) Human MICU3 1:3~1:6 Negative Online Inquiry
KO16174 MICU3 Knockout cell line (A549) Human MICU3 1:3~1:4 Negative Online Inquiry

Background

MICU3 Gene Knockout Cell Lines are engineered cellular models specifically designed to study the role of the MICU3 gene in mitochondrial calcium uptake and homeostasis. These cell lines are created using advanced CRISPR-Cas9 technology to achieve precise gene disruption, facilitating detailed investigations into the physiological functions of MICU3. By eliminating the MICU3 gene, researchers can assess the consequences on mitochondrial function, cellular metabolism, and related signaling pathways, providing invaluable insights into mitochondrial biology.

The primary function of the MICU3 gene is to regulate calcium ion influx into the mitochondria, which is critical for numerous metabolic processes, including ATP production and reactive oxygen species (ROS) regulation. In-depth analysis of these knockout cell lines enables scientists to elucidate the intricate mechanisms of mitochondrial calcium signaling, potentially linking dysregulation to various diseases, including neurodegenerative disorders and metabolic syndromes. Furthermore, these cell lines serve as a robust platform for drug screening, providing a means to explore therapeutic agents aimed at modulating mitochondrial function.

The scientific importance of MICU3 Gene Knockout Cell Lines extends to both fundamental research and clinical applications. They offer a unique opportunity to identify novel drug targets and biomarkers associated with mitochondrial dysfunction. Compared to traditional cell lines, these genetic models provide greater accuracy and reproducibility in experimental outcomes, making them indispensable tools in modern biomedical research.

Our MICU3 Gene Knockout Cell Lines stand apart from alternatives due to their high specificity, validated genetic modification, and compatibility with various in vitro assays. This not only accelerates the pace of discovery but also enhances the reliability of the data obtained, addressing the challenges researchers face in obtaining consistent results.

In conclusion, leveraging our expertise in gene editing and cellular biology, we provide cutting-edge products that meet the diverse needs of researchers and clinicians aiming to unlock the complexities of mitochondrial dynamics. Our commitment to quality and innovation ensures that you receive reliable and relevant tools to advance your research endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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