Gene: MICB
Official Full Name: MHC class I polypeptide-related sequence Bprovided by HGNC
Gene Summary: This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO36633 | MICB Knockout cell line (HeLa) | Human | MICB | 1:3~1:6 | Negative | Online Inquiry |
KO36634 | MICB Knockout cell line (HCT 116) | Human | MICB | 1:2~1:4 | Negative | Online Inquiry |
KO36635 | MICB Knockout cell line (HEK293) | Human | MICB | 1:3~1:6 | Negative | Online Inquiry |
KO36636 | MICB Knockout cell line (A549) | Human | MICB | 1:3~1:4 | Negative | Online Inquiry |
MICB Gene Knockout Cell Lines are genetically engineered cell lines that have undergone targeted gene disruption to eliminate the expression of the MICB gene, which plays a crucial role in immune response regulation and tumor recognition. By creating a cellular model devoid of this gene, researchers can study its biological functions in-depth and understand its implications in various physiological and pathological conditions, including tumor immunity and autoimmune diseases.
The key function of MICB gene knockout cell lines lies in their ability to mimic disease states by providing a controlled environment to observe how the absence of MICB influences various cellular pathways. This involves intricate mechanisms such as altered immune evasion tactics of tumors, changes in cell signaling related to immune checkpoints, and variations in apoptosis resistance. Cells lacking MICB can be pivotal in dissecting the roles of immune modulation and potentially discovering new therapeutic targets.
The scientific importance of these cell lines extends into both research and clinical arenas. In research, they facilitate the examination of immune responses in a system that isolates variable genetic factors, making them invaluable for studies aimed at understanding tumor microenvironments and the dynamics of immune interactions. Clinically, this knowledge could lead to breakthroughs in personalized medicine approaches where targeted therapies are tailored based on the genetic landscape of tumors.
One significant advantage of our MICB Gene Knockout Cell Lines is the precision of the gene editing technology employed, which significantly reduces off-target effects compared to traditional knockout methods. This high specificity ensures that researchers can obtain reproducible and reliable results across multiple experimental platforms. Furthermore, our cell lines come with comprehensive documentation, including detailed characterization data and growth conditions, enabling seamless integration into existing research workflows.
For researchers and clinicians seeking innovative and accurate models to probe the complexities of immune evasion and therapeutic resistance, MICB Gene Knockout Cell Lines provide an unparalleled resource. By utilizing these cutting-edge cell lines, users can drive more profound scientific insights that could ultimately inform better therapeutic strategies.
Our company prides itself on its robust foundation in molecular biology and genetics, specializing in state-of-the-art cell line development. With a commitment to high-quality products and customer support, we empower the scientific community to advance their research endeavors and enhance our understanding of complex biological systems.
Please note that all services are for research use only. Not intended for any clinical use.
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