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MICALL1 Knockout Cell Lines

Gene: MICALL1

Official Full Name: MICAL like 1provided by HGNC

Gene Summary: Enables identical protein binding activity; phosphatidic acid binding activity; and small GTPase binding activity. Involved in several processes, including plasma membrane tubulation; protein localization to endosome; and slow endocytic recycling. Located in cytoplasmic side of endosome membrane; late endosome; and recycling endosome membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO24258 MICALL1 Knockout cell line (HeLa) Human MICALL1 1:3~1:6 Negative Online Inquiry
KO24259 MICALL1 Knockout cell line (HCT 116) Human MICALL1 1:2~1:4 Negative Online Inquiry
KO24260 MICALL1 Knockout cell line (HEK293) Human MICALL1 1:3~1:6 Negative Online Inquiry
KO24261 MICALL1 Knockout cell line (A549) Human MICALL1 1:3~1:4 Negative Online Inquiry

Background

MICALL1 Gene Knockout Cell Lines are a set of genetically modified cell lines in which the MICALL1 gene has been selectively disrupted. This alteration facilitates in-depth studies of the gene's biological functions and its role in various physiological and pathological processes. Utilizing CRISPR-Cas9 gene-editing technology, these knockout cell lines provide a robust platform for investigating the cellular mechanisms impacted by the absence of MICALL1, a gene implicated in cellular signaling pathways and tissue homeostasis.

Functionally, MICALL1 knockout cell lines enable researchers to elucidate the gene's contribution to critical pathways such as endocytosis, cell migration, and the modulation of immune responses. The functionality is largely attributed to the cell lines' capacity to mimic natural cellular environments while lacking the MICALL1 expression, thus serving as a powerful tool for cell-based assays, drug screening, and mechanistic studies.

The scientific importance of these cell lines is noteworthy in both research and clinical applications. For instance, the understanding of MICALL1's role in diseases, including cancer and autoimmune disorders, can be enhanced through these models, potentially leading to novel therapeutic strategies. They are particularly valuable for researchers focused on cell biology, immunology, and therapeutic development.

Compared to alternative approaches, such as transient transfection or siRNA knockdown, MICALL1 gene knockout cell lines offer a stable and persistent genetic modification, which reduces variability and increases the reproducibility of experimental outcomes. Furthermore, their ease of use in various assay formats allows for efficient integration into existing workflows.

For researchers and clinicians seeking reliable models to explore gene function and disease mechanisms, MICALL1 Gene Knockout Cell Lines present a compelling option. Their contribution to advancing our understanding of cellular dynamics makes them indispensable in the toolbox of molecular biologists.

With a commitment to excellence and innovation, our company specializes in the development of high-quality biological reagents and models, ensuring that researchers have access to the most precise tools for advancing their work in the life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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