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MGP Knockout Cell Lines

Gene: MGP

Official Full Name: matrix Gla proteinprovided by HGNC

Gene Summary: This gene encodes a member of the osteocalcin/matrix Gla family of proteins. The encoded vitamin K-dependent protein is secreted by chondrocytes and vascular smooth muscle cells, and functions as a physiological inhibitor of ectopic tissue calcification. Carboxylation status of the encoded protein is associated with calcification of the vasculature in human patients with cardiovascular disease and calcification of the synovial membranes in osteoarthritis patients. Mutations in this gene cause Keutel syndrome in human patients, which is characterized by abnormal cartilage calcification, peripheral pulmonary stenosis and facial hypoplasia. [provided by RefSeq, Sep 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO36649 MGP Knockout cell line (HeLa) Human MGP 1:3~1:6 Negative Online Inquiry

Background

MGP Gene Knockout Cell Lines are engineered cellular models that have been meticulously crafted to specifically disable the expression of the Matrix Gla Protein (MGP) gene. These cell lines utilize advanced CRISPR-Cas9 technology to achieve precise genome editing, allowing researchers to investigate the role of MGP in various biological processes and disease mechanisms. By silencing MGP gene expression, scientists can explore its functions in ossification, vascular calcification, and other critical physiological pathways.

The primary function of MGP Gene Knockout Cell Lines is to facilitate the elucidation of the molecular and cellular pathways influenced by MGP deficiency. These cell lines provide a controlled environment for studying gene function and regulation, enabling researchers to conduct assays that assess cellular responses to various stimuli, including calcium and phosphorus levels. Furthermore, the knockout model serves as a vital tool for examining the potential therapeutic implications of targeting MGP-related pathways in conditions such as cardiovascular disease and bone metabolism disorders.

The scientific significance of these cell lines lies in their potential to advance our understanding of the pathophysiology associated with MGP. By utilizing these models, researchers can uncover novel insights that can inform the development of new therapeutic strategies or diagnostic tools in clinical settings. Moreover, MGP Gene Knockout Cell Lines offer a superior alternative to traditional methods; they provide not only an effective means of generating loss-of-function models but also save considerable time and resources compared to the established knockdown techniques.

One of the unique selling points of our MGP Gene Knockout Cell Lines is their high specificity and efficiency in gene disruption, which contributes to reproducible and reliable experimental results. In addition, these cell lines can be readily adapted for high-throughput screening, providing researchers with the flexibility to explore various experimental conditions without the extensive optimization often associated with traditional models.

In conclusion, the value of MGP Gene Knockout Cell Lines is clear for researchers and clinicians aiming to explore the complex roles of MGP in health and disease. With a commitment to advancing scientific knowledge and offering innovative biological products, our company is dedicated to supporting the research community with high-quality, reliable cell lines that enhance experimental efficiency and accuracy.

Please note that all services are for research use only. Not intended for any clinical use.

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