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MFSD8 Knockout Cell Lines

Gene: MFSD8

Official Full Name: major facilitator superfamily domain containing 8provided by HGNC

Gene Summary: This gene encodes a ubiquitous integral membrane protein that contains a transporter domain and a major facilitator superfamily (MFS) domain. Other members of the major facilitator superfamily transport small solutes through chemiosmotic ion gradients. The substrate transported by this protein is unknown. The protein likely localizes to lysosomal membranes. Mutations in this gene are correlated with a variant form of late infantile-onset neuronal ceroid lipofuscinoses (vLINCL). [provided by RefSeq, Oct 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
GP00491 MFSD8 gRNA5 KO plasmid MFSD8 $850
GP00551 MFSD8 gRNA5-gRNA6 KO plasmid MFSD8 $850
KO00792 MFSD8 Knockout cell line(293T) Human MFSD8 1:3~1:6 Negative Online Inquiry
KO01269 MFSD8 Knockout cell line (COS-1) Green monkey MFSD8 Negative Online Inquiry
KO16202 MFSD8 Knockout cell line (HeLa) Human MFSD8 1:3~1:6 Negative Online Inquiry
KO16203 MFSD8 Knockout cell line (HCT 116) Human MFSD8 1:2~1:4 Negative Online Inquiry
KO16204 MFSD8 Knockout cell line (HEK293) Human MFSD8 1:3~1:6 Negative Online Inquiry
KO16205 MFSD8 Knockout cell line (A549) Human MFSD8 1:3~1:4 Negative Online Inquiry

Background

MFSD8 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to lack the expression of the MFSD8 gene. The MFSD8 gene encodes for a membrane transporter protein that plays a significant role in lipid metabolism and cellular function. By creating a knockout of this gene, researchers can investigate the downstream effects of its absence, which is critical for understanding various biological processes, including those involved in cellular stress responses and neurodegenerative disease mechanisms.

These cell lines function by allowing scientists to observe the phenotypic and molecular consequences of MFSD8 deficiency. The mechanisms studied may involve altered lipid metabolism, changes in cellular signaling pathways, and the impact on cellular homeostasis and viability. Researchers can utilize these knockout lines in experiments aimed at elucidating the role of MFSD8 in disease models or exploring therapeutic interventions that target lipid transport mechanisms.

The scientific importance of MFSD8 Gene Knockout Cell Lines extends into several research areas, including neurobiology, metabolic diseases, and cancer research. They serve as invaluable tools for validating targets for drug discovery and developing gene therapy strategies. Given that MFSD8 has been implicated in conditions such as Batten disease and other lysosomal storage disorders, these cell lines are crucial for studying pathogenic mechanisms and testing potential treatments in a controlled laboratory environment.

What sets our MFSD8 Gene Knockout Cell Lines apart from alternatives is their high specificity and reproducibility. Developed using advanced CRISPR-Cas9 technology, these cell lines ensure precise gene editing, providing more reliable and consistent results across various experimental setups. Furthermore, we offer comprehensive technical support and related reagents to facilitate the research process, enhancing the usability and accessibility of our product.

Researchers and clinicians seeking to deepen their understanding of cellular mechanisms influenced by MFSD8 will find our knockout cell lines valuable assets. They not only provide a powerful platform for exploring gene function but also contribute to advancing targeted therapies. As a company, we pride ourselves on our expertise in molecular biology and genetics, dedicated to providing high-quality biological products that propel scientific discovery and innovation.

Please note that all services are for research use only. Not intended for any clinical use.

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