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METTL8 Knockout Cell Lines

Gene: METTL8

Official Full Name: methyltransferase 8, tRNA N3-cytidineprovided by HGNC

Gene Summary: Enables mRNA methyltransferase activity and tRNA (cytidine-3-)-methyltransferase activity. Involved in RNA metabolic process and positive regulation of mitochondrial translation. Is active in mitochondrial matrix. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO16232 METTL8 Knockout cell line (HeLa) Human METTL8 1:3~1:6 Negative Online Inquiry
KO16233 METTL8 Knockout cell line (HCT 116) Human METTL8 1:2~1:4 Negative Online Inquiry
KO16234 METTL8 Knockout cell line (HEK293) Human METTL8 1:3~1:6 Negative Online Inquiry
KO16235 METTL8 Knockout cell line (A549) Human METTL8 1:3~1:4 Negative Online Inquiry

Background

METTL8 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to investigate the functional role of the METTL8 gene within cellular processes. By employing CRISPR-Cas9 gene-editing technology, these cell lines feature a precise deletion of the METTL8 gene, allowing researchers to explore its biological implications and mechanisms in various contexts. The METTL8 gene has been associated with critical cellular functions, including RNA methylation and the regulation of gene expression, making its study essential for understanding diverse biological phenomena.

These knockout cell lines enable scientists to conduct robust mechanistic studies and perform high-throughput screening assays to decipher the gene's role in processes such as cellular differentiation, response to stress, and potential links to pathogenic states. Their application spans fundamental research, drug discovery, and translational medicine, providing invaluable insights that could lead to novel therapeutic interventions.

The primary advantage of using METTL8 Gene Knockout Cell Lines lies in their specificity and reliability. Unlike conventional models that may present heterogeneous expression levels or off-target effects, these knockout lines ensure that any observed phenotypes are directly attributable to the absence of METTL8. This specificity significantly enhances the validity of experimental results, providing a clearer understanding of the gene's contributions to health and disease.

Researchers and clinicians will find these cell lines particularly valuable due to their ability to facilitate targeted investigations into METTL8-related pathways and their potential links to various diseases, including cancer and neurodegenerative disorders. With the growing focus on RNA modification in the field of epitranscriptomics, the METTL8 Gene Knockout Cell Lines represent a cutting-edge tool for advancing our understanding of gene regulation and therapeutic exploration.

Our company prides itself on being at the forefront of genetic research tools, offering a comprehensive suite of products that empower scientists to push the boundaries of discovery. With a proven track record in genetic engineering, we are committed to supporting the scientific community in achieving groundbreaking advancements through our innovative products.

Please note that all services are for research use only. Not intended for any clinical use.

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