Gene: MDM1
Official Full Name: Mdm1 nuclear proteinprovided by HGNC
Gene Summary: This gene encodes a microtubule-binding nuclear protein that localizes to the centrioles of dividing cells and differentiating multiciliated cells and negatively regulates centriole duplication. The encoded protein is closely associated with the centriole barrel, and resides in the centriole lumen. Naturally-occurring mutations in the orthologous mouse gene are associated with age-related retinal degeneration. [provided by RefSeq, Feb 2019]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO16274 | MDM1 Knockout cell line (HeLa) | Human | MDM1 | 1:3~1:6 | Negative | Online Inquiry |
KO16275 | MDM1 Knockout cell line (HCT 116) | Human | MDM1 | 1:2~1:4 | Negative | Online Inquiry |
KO16276 | MDM1 Knockout cell line (HEK293) | Human | MDM1 | 1:3~1:6 | Negative | Online Inquiry |
KO16277 | MDM1 Knockout cell line (A549) | Human | MDM1 | 1:3~1:4 | Negative | Online Inquiry |
MDM1 Gene Knockout Cell Lines are specially engineered cellular models where the MDM1 gene has been inactivated, allowing for the study of the gene's function and its implications in various biological processes, including cell cycle regulation and apoptosis. The targeted knockout of the MDM1 gene is achieved through advanced CRISPR/Cas9 genome editing technologies, providing researchers with a powerful tool to investigate gene function without the interference of MDM1's protein products.
The primary mechanism of action involves the disruption of the MDM1 gene, leading to the absence of MDM1 protein expression. This knockout model aids researchers in understanding the role of MDM1 in cellular stress responses, tumorigenesis, and the modulation of p53 activity. By elucidating these pathways, scientists can glean insights into the molecular underpinnings of cancer biology and other diseases linked to dysregulation in apoptotic pathways.
In research and clinical settings, MDM1 Gene Knockout Cell Lines hold significant importance. They serve as invaluable resources for drug development and therapeutic testing, as well as providing platforms for studying gene function and disease mechanisms. The ability to create precise genetic models that mimic human disease conditions allows for more relevant and translatable findings.
What sets MDM1 Gene Knockout Cell Lines apart from conventional knockouts or wild-type cell lines is their precision and efficiency in gene targeting. Alternatives may suffer from incomplete gene disruption or off-target effects; however, our lines ensure a reliable and reproducible system for gene functional studies, facilitating higher confidence in experimental results.
Researchers and clinicians looking to deepen their understanding of MDM1-associated pathways or develop novel therapeutic strategies will find tremendous value in these knockout cell lines. As experts in biological products, our commitment to providing high-quality, rigorously validated models ensures that our offerings empower the scientific community to achieve breakthroughs that could lead to innovative treatments and advancements in medical research.
Please note that all services are for research use only. Not intended for any clinical use.
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