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MCM9 Knockout Cell Lines

Gene: MCM9

Official Full Name: minichromosome maintenance 9 homologous recombination repair factorprovided by HGNC

Gene Summary: The protein encoded by this gene is a member of the mini-chromosome maintenance (MCM) protein family that are essential for the initiation of eukaryotic genome replication. Binding of this protein to chromatin has been shown to be a pre-requisite for recruiting the MCM2-7 helicase to DNA replication origins. This protein also binds, and is a positive regulator of, the chromatin licensing and DNA replication factor 1, CDT1. [provided by RefSeq, Nov 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO21156 MCM9 Knockout cell line (HeLa) Human MCM9 1:3~1:6 Negative Online Inquiry
KO21157 MCM9 Knockout cell line (HCT 116) Human MCM9 1:2~1:4 Negative Online Inquiry
KO21158 MCM9 Knockout cell line (HEK293) Human MCM9 1:3~1:6 Negative Online Inquiry
KO21159 MCM9 Knockout cell line (A549) Human MCM9 1:3~1:4 Negative Online Inquiry

Background

MCM9 Gene Knockout Cell Lines are genetically engineered cellular models specifically designed to lack the MCM9 gene, which is crucial for maintaining genomic stability and proper DNA replication. These cell lines serve as a valuable experimental tool for researchers investigating the roles of MCM9 in cell cycle regulation, DNA repair mechanisms, and the pathways that lead to malignancies.

The primary function of MCM9 gene knockout cell lines is to elucidate the contributions of MCM9 to cellular processes such as DNA replication, response to replication stress, and maintenance of genomic integrity. By observing the phenotypic and molecular changes that occur in these knockout lines, scientists can dissect the regulatory pathways that are affected, revealing new insights into cancer biology, cellular aging, and potential therapeutic targets.

The scientific significance of MCM9 gene knockout cell lines is profound; they are instrumental in functional genomics and can be utilized in drug discovery efforts aimed at developing novel therapies for cancers with compromised DNA repair capabilities. Researchers can explore pathways that can be exploited for targeted therapies, making these cell lines essential in both basic and translational research.

Compared to other cell models, MCM9 gene knockout cell lines offer a precise and specific alteration of a singular gene, allowing for the focused study of its unique biological functions without the confounding effects seen in partial knockdowns or overexpression systems. This specificity enhances the reproducibility and interpretability of experimental results, which is crucial for advancing our understanding of molecular biology.

The value of MCM9 gene knockout cell lines lies in their ability to aid researchers and clinicians in developing a deeper understanding of diseases associated with DNA replication and repair defects. This knowledge not only lays the groundwork for innovative therapeutic strategies but also enhances the overall quality of research outputs.

With expertise in the development and production of high-quality biological models, our company is committed to providing leading-edge research tools that empower scientists across various fields of study. Our MCM9 Gene Knockout Cell Lines reflect our dedication to advancing scientific inquiry and contributing to the translation of research findings into effective clinical applications.

Please note that all services are for research use only. Not intended for any clinical use.

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