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MCC Knockout Cell Lines

Gene: MCC

Official Full Name: MCC regulator of WNT signaling pathwayprovided by HGNC

Gene Summary: This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO04245 MCC Knockout cell line (HeLa) Human MCC 1:3~1:6 Negative Online Inquiry
KO04246 MCC Knockout cell line (HCT 116) Human MCC 1:2~1:4 Negative Online Inquiry
KO04247 MCC Knockout cell line (HEK293) Human MCC 1:3~1:6 Negative Online Inquiry

Background

MCC Gene Knockout Cell Lines are genetically engineered cell lines in which the MCC (mutated in colon cancer) gene has been selectively disrupted, creating a model that facilitates the study of gene function and its implications in various biological pathways. These cell lines are established using advanced CRISPR-Cas9 technology, which allows for precise gene editing, resulting in the ablation of MCC expression and providing a powerful tool for researchers examining tumorigenesis and other related cellular processes.

The primary function of MCC Gene Knockout Cell Lines is to serve as a model system for exploring the downstream effects of MCC gene loss, including alterations in cell proliferation, apoptosis, and tumor growth. By understanding the role of MCC in these pathways, researchers can glean insights into colorectal cancer biology and other malignancies, opening avenues for innovative therapeutic strategies. The manipulation of these cell lines can illuminate the contributions of MCC to signaling pathways such as the Wnt pathway, which plays a critical role in cancer progression.

The scientific importance of MCC Gene Knockout Cell Lines is significant, as they provide a framework for elucidating the mechanisms by which tumor suppressor genes contribute to cancer development. Their applications extend to drug screening, biomarker discovery, and the validation of therapeutic targets in both preclinical and clinical research settings.

What sets MCC Gene Knockout Cell Lines apart from other genetic models is their specificity and reliability. Unlike traditional knockout models that may suffer from off-target effects, these cell lines are rigorously validated for precise gene disruption, ensuring confidence in experimental results. Furthermore, they are genetically homogeneous, providing consistency that is crucial in reproducibility and comparative studies.

For researchers and clinicians seeking to unravel the complexities of cancer biology, investing in MCC Gene Knockout Cell Lines represents an invaluable opportunity. Our product not only enhances the understanding of tumorigenic processes but also strengthens the pipeline for the development of targeted therapies. By choosing our MCC Gene Knockout Cell Lines, you are leveraging the expertise of a company dedicated to advancing genetic research through innovative technologies and high-quality biological products.

Please note that all services are for research use only. Not intended for any clinical use.

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