Home / MBTPS1 Knockout Cell Lines

MBTPS1 Knockout Cell Lines

Gene: MBTPS1

Official Full Name: membrane bound transcription factor peptidase, site 1provided by HGNC

Gene Summary: This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the cis/medial-Golgi where a second autocatalytic event takes place and the catalytic activity is acquired. It encodes a type 1 membrane bound protease which is ubiquitously expressed and regulates cholesterol or lipid homeostasis via cleavage of substrates at non-basic residues. Mutations in this gene may be associated with lysosomal dysfunction. [provided by RefSeq, Feb 2014]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO09469 MBTPS1 Knockout cell line (HeLa) Human MBTPS1 1:3~1:6 Negative Online Inquiry
KO09470 MBTPS1 Knockout cell line (HCT 116) Human MBTPS1 1:2~1:4 Negative Online Inquiry
KO09471 MBTPS1 Knockout cell line (HEK293) Human MBTPS1 1:3~1:6 Negative Online Inquiry

Background

MBTPS1 Gene Knockout Cell Lines are specifically engineered cellular models in which the MBTPS1 gene, known for its role in the unconventional protein secretion pathway and cellular stress response, has been completely inactivated. This product serves as a pivotal tool for researchers investigating the biological functions of the MBTPS1 gene, its involvement in diseases, and its potential as a therapeutic target.

These cell lines operate by utilizing CRISPR-Cas9 technology to create precise gene disruptions that help elucidate the functions associated with the ER stress response and cellular homeostasis. By knocking out the MBTPS1 gene, researchers can observe resultant phenotypic changes that provide insights into its regulatory mechanisms and contribute to a better understanding of various pathologies, including neurodegenerative diseases and certain cancers.

The scientific relevance of MBTPS1 Gene Knockout Cell Lines extends into both basic and applied research. In clinical settings, they can be employed to study the molecular underpinnings of diseases linked to misfolded proteins, offering a robust platform for drug discovery and validation of therapeutic compounds. Their utility extends into translational research, where elucidating the mechanisms of stress responses can lead to the development of better treatment strategies.

What sets these cell lines apart from other genetic models is their high specificity and reliability, as they are developed under stringent quality control measures to ensure consistent knockout efficiency. Additionally, the MBTPS1 Gene Knockout Cell Lines come with comprehensive support, including detailed protocols and customization options, thereby facilitating researchers' work in various experimental paradigms.

For researchers and clinicians seeking to deepen their understanding of cellular protein management and stress responses, these knockout cell lines represent an invaluable asset. With our company’s extensive expertise in producing high-quality biological products, we are dedicated to supporting advancements in biomedical research and therapy development through our innovative offerings.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.