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MBD1 Knockout Cell Lines

Gene: MBD1

Official Full Name: methyl-CpG binding domain protein 1provided by HGNC

Gene Summary: The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains multiple domains: MBD at the N-terminus that functions both in binding to methylated DNA and in protein interactions; several CXXC-type zinc finger domains that mediate binding to non-methylated CpG dinucleotides; transcriptional repression domain (TRD) at the C-terminus that is involved in transcription repression and in protein interactions. Numerous alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Feb 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO03593 MBD1 Knockout cell line (HeLa) Human MBD1 1:3~1:6 Negative Online Inquiry
KO03594 MBD1 Knockout cell line (HCT 116) Human MBD1 1:2~1:4 Negative Online Inquiry
KO03595 MBD1 Knockout cell line (HEK293) Human MBD1 1:3~1:6 Negative Online Inquiry
KO03596 MBD1 Knockout cell line (A549) Human MBD1 1:3~1:4 Negative Online Inquiry

Background

MBD1 Gene Knockout Cell Lines are specifically engineered cellular models where the MBD1 (Methyl-CpG Binding Domain Protein 1) gene has been selectively inactivated. This innovative tool serves as a vital resource for studying gene function and regulation associated with epigenetic modifications. MBD1 is known to play a crucial role in transcriptional repression and chromatin remodeling, as it binds to methylated DNA, influencing gene expression profiles. By utilizing these knockout cell lines, researchers can elucidate the biological pathways affected by MBD1 loss, enabling a deeper understanding of epigenetic mechanisms in various cellular processes.

The primary function of MBD1 Gene Knockout Cell Lines is to provide a clear context for investigating the effects of MBD1 absence on gene expression, cellular viability, and differentiation processes. The disruption of this gene allows for the exploration of its contributions to diseases associated with epigenetic dysregulation, including cancer and neurological disorders. These cell lines can be particularly useful for drug discovery, as they allow the assessment of therapeutic targets and the exploration of the efficacy of epigenetic modulators.

The scientific importance of MBD1 Gene Knockout Cell Lines extends to their applications in both basic and translational research. Their use in functional genomics enables scientists to conduct experiments that dissect the role of MBD1 in cellular pathways, making them indispensable for studies focused on epigenetics and gene regulation.

Compared to traditional cell lines, the knockout model provides a more accurate representation of the absence of MBD1 and its effects on cell behavior. This specificity removes the ambiguity often associated with partial inhibition using pharmacological agents. Furthermore, while other gene knockout technologies exist, the precision and reliability of these cell lines derived from rigorous genetic engineering techniques ensure robust experimental outcomes.

For researchers and clinicians, the value of MBD1 Gene Knockout Cell Lines lies in their ability to unlock previously inaccessible avenues of biological exploration. These cell lines empower scientists to translate their findings into clinical insights, bridging the gap between bench-side innovation and bedside application.

Our company is committed to advancing the field of biological research by offering high-quality, rigorously validated cell lines that support groundbreaking scientific endeavors. With expertise in genetic engineering and cellular biology, we are proud to provide researchers with the essential tools they need to push the boundaries of discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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