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MATN2 Knockout Cell Lines

Gene: MATN2

Official Full Name: matrilin 2provided by HGNC

Gene Summary: This gene encodes a member of the von Willebrand factor A domain containing protein family. This family of proteins is thought to be involved in the formation of filamentous networks in the extracellular matrices of various tissues. This protein contains five von Willebrand factor A domains. The specific function of this gene has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO36696 MATN2 Knockout cell line (HeLa) Human MATN2 1:3~1:6 Negative Online Inquiry
KO36697 MATN2 Knockout cell line (HCT 116) Human MATN2 1:2~1:4 Negative Online Inquiry
KO36698 MATN2 Knockout cell line (HEK293) Human MATN2 1:3~1:6 Negative Online Inquiry
KO36699 MATN2 Knockout cell line (A549) Human MATN2 1:3~1:4 Negative Online Inquiry

Background

MATN2 Gene Knockout Cell Lines are sophisticated biological tools designed to facilitate in-depth studies of the matrilin-2 (MATN2) gene, which is essential for the structural integrity of the extracellular matrix and involved in various physiological processes. These cell lines are engineered through CRISPR-Cas9 gene editing technology to create specific knockouts of the MATN2 gene, allowing researchers to explore the resultant phenotypic variations and their implications in tissue development, repair, and disease states.

The primary function of MATN2 Gene Knockout Cell Lines is to provide a model system for assessing the role of MATN2 in cellular processes such as adhesion, migration, and proliferation. By analyzing these knockout models, researchers can elucidate the gene's contribution to matrix organization and its effects on cellular behavior, offering insights into conditions such as osteoarthritis and various forms of cancer, where MATN2 expression may be dysregulated.

The scientific importance of these cell lines lies in their application in both basic and translational research. They enable advanced studies into extracellular matrix dynamics and can serve as a powerful platform for drug development, allowing researchers to evaluate potential therapeutic interventions targeting MATN2-related pathways.

What sets MATN2 Gene Knockout Cell Lines apart from traditional cell models is their precision and the significant reduction in off-target effects typical of earlier gene-editing technologies. This precision enhances the reliability of experimental outcomes while providing a cost-effective and time-efficient alternative to other genomic manipulation techniques.

For researchers and clinicians, the value of MATN2 Gene Knockout Cell Lines extends beyond academic curiosity; they represent a critical resource for unraveling complex disease mechanisms and developing new therapeutic approaches. Incorporating these advanced cell lines into research workflows can lead to breakthroughs in understanding tissue-related diseases and foster innovation in clinical applications.

Our company prides itself on its commitment to scientific advancement and excellence in product offerings, making MATN2 Gene Knockout Cell Lines a noteworthy asset for labs dedicated to cutting-edge research.

Please note that all services are for research use only. Not intended for any clinical use.

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