Gene: MATK
Official Full Name: megakaryocyte-associated tyrosine kinaseprovided by HGNC
Gene Summary: The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO02331 | MATK Knockout cell line (HEK293) | Human | MATK | 1:3~1:6 | Negative | Online Inquiry |
MATK Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to lack the expression of the MATK (megakaryocyte-associated tyrosine kinase) gene. These knockout cell lines serve as invaluable tools for understanding the biological roles of MATK in various cellular processes, including hematopoiesis, cell signaling, and immune responses. By utilizing CRISPR-Cas9 technology or other gene-editing methodologies, researchers can systematically investigate the functional consequences of MATK deficiency, offering insights into its impact on cellular proliferation, differentiation, and apoptosis.
Key functions of the MATK Gene Knockout Cell Lines allow researchers to dissect complex signaling pathways that involve tyrosine kinases, particularly in the context of megakaryocyte and lymphocyte biology. The knockout of MATK provides a robust model for exploring how the loss of this gene influences cell behavior and contributes to various disease states, such as hematological disorders or immune dysregulation.
In a clinical research landscape where understanding gene function is essential for developing targeted therapies, these knockout cell lines become crucial for validating potential drug targets. They allow for high-throughput screening of novel compounds and can facilitate the development of immunotherapies by illustrating how MATK influences immune cell functions.
What sets our MATK Gene Knockout Cell Lines apart from alternatives is their rigorously validated background, ensuring reproducibility and reliability in experimental outcomes. Our product comes with comprehensive documentation, including the genomic characterization of the knockout, functional assays, and support for troubleshooting and experimental design.
For researchers and clinicians aiming to elucidate the roles of specific genes in human health and disease, our MATK Gene Knockout Cell Lines represent an essential resource. They empower scientists to translate fundamental research into meaningful therapeutic applications. With a strong background in genetic engineering and cell biology, our company excels in delivering high-quality biological products that meet the highest standards of scientific rigor, supporting the research community's quest for discovery.
Please note that all services are for research use only. Not intended for any clinical use.
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