Gene: MAT2A
Official Full Name: methionine adenosyltransferase 2Aprovided by HGNC
Gene Summary: The protein encoded by this gene catalyzes the production of S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is the key methyl donor in cellular processes. [provided by RefSeq, Jun 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
GP00511 | MAT2A gRNA1-gRNA2 KO plasmid | MAT2A | $850 | |||
KO00763 | MAT2A Knockout cell line (Hep G2) | Human | MAT2A | 1:2~1:4 | Negative | Online Inquiry |
MAT2A Gene Knockout Cell Lines are genetically modified cell lines in which the MAT2A gene, encoding the methionine adenosyltransferase 2A, has been specifically disrupted. This knockout leads to reduced levels of S-adenosylmethionine (SAM), a critical methyl donor involved in numerous biological processes, including nucleic acid methylation and the regulation of gene expression. The disruption of MAT2A elucidates the gene's function and offers researchers a powerful tool for studying the biochemical pathways and cellular responses related to SAM metabolism.
The key functionality of MAT2A Gene Knockout Cell Lines lies in the ability to investigate the consequences of diminished SAM levels on cellular physiology and pathology. These cell lines can be utilized to explore various biological processes such as cell growth, differentiation, and response to stress, providing insights into the roles of methionine metabolism in health and disease. By studying these cells, researchers can elucidate mechanisms underlying metabolic disorders, cancer progression, and other diseases linked to dysregulated methylation.
In both research and clinical settings, the scientific importance of MAT2A Knockout Cell Lines is profound. They serve as a model for understanding the implications of SAM in metabolic pathways and provide a platform for drug discovery and development. This is particularly relevant in cancer research, where alterations in cellular metabolism and methylation patterns are crucial.
Compared to conventional cell lines, the MAT2A Gene Knockout Cell Lines stand out due to their specificity and reproducibility in studying the effects of SAM depletion. They present a novel approach to understanding the implications of methylation and cellular metabolism, presenting an opportunity for targeted therapeutic interventions.
For researchers and clinicians, the value of MAT2A Gene Knockout Cell Lines lies in their ability to facilitate cutting-edge studies that may unveil new diagnostic markers or therapeutic targets. As experts in producing high-quality biological products, our company is committed to advancing scientific research by providing innovative tools that enable breakthroughs in understanding complex biological processes.
Please note that all services are for research use only. Not intended for any clinical use.
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