Gene: MARVELD3
Official Full Name: MARVEL domain containing 3provided by HGNC
Gene Summary: Enables mitogen-activated protein kinase kinase kinase binding activity. Involved in bicellular tight junction assembly. Acts upstream of or within several processes, including negative regulation of JNK cascade; negative regulation of epithelial cell migration; and protein localization to cell junction. Located in bicellular tight junction and cytoplasmic vesicle. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO23334 | MARVELD3 Knockout cell line (HCT 116) | Human | MARVELD3 | 1:2~1:4 | Negative | Online Inquiry |
KO23335 | MARVELD3 Knockout cell line (HEK293) | Human | MARVELD3 | 1:3~1:6 | Negative | Online Inquiry |
MARVELD3 Gene Knockout Cell Lines are specifically engineered cellular models designed to facilitate the study of the MARVELD3 gene, which plays a crucial role in regulating cellular processes such as migration, invasion, and immune response modulation. By employing CRISPR-Cas9 technology, these cell lines exhibit a complete absence of functional MARVELD3 protein, providing a robust platform to explore the gene's implications in various biological contexts.
The primary mechanism of the MARVELD3 Gene Knockout Cell Lines involves the targeted disruption of the MARVELD3 gene, leading to the comprehensive knockout of its expression. This allows researchers to rigorously assess downstream effects on cellular pathways related to cancer development, immunological responses, and neurodegenerative diseases. The availability of these knockout models allows scientists to observe changes in phenotypic characteristics and signaling dynamics that would otherwise be masked in wild-type cells.
The scientific importance of these cell lines extends to their applications in both research and clinical settings. They enable the investigation of MARVELD3's role in pathophysiology, offering potential insights into therapeutic targets for diseases such as cancer and autoimmune disorders. By utilizing these cell lines, researchers can develop targeted therapies and tailor personalized medicine approaches that are essential in modern biomedicine.
Compared to traditional methods, such as RNA interference, MARVELD3 Gene Knockout Cell Lines offer permanent and heritable gene disruptions, allowing for the consistent study of gene function over time. Moreover, these cell lines are validated for use in various assays, ensuring reliability and reproducibility in experimental outcomes.
For researchers, clinicians, and biopharmaceutical companies, the value of the MARVELD3 Gene Knockout Cell Lines lies in their ability to provide precise and unambiguous data on gene function and its associated biological pathways. This makes them an essential tool in gene function study and drug development.
Our company prides itself on a commitment to excellence in genetic engineering and biotechnology, providing unmatched expertise in the development of state-of-the-art cell lines that meet the rigorous demands of contemporary biological research. With the MARVELD3 Gene Knockout Cell Lines, we are dedicated to supporting the scientific community in advancing the frontiers of knowledge and therapeutic applications.
Please note that all services are for research use only. Not intended for any clinical use.
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