Gene: MARVELD2
Official Full Name: MARVEL domain containing 2provided by HGNC
Gene Summary: The protein encoded by this gene is a membrane protein found at the tight junctions between epithelial cells. The encoded protein helps establish epithelial barriers such as those in the organ of Corti, where these barriers are required for normal hearing. Defects in this gene are a cause of deafness autosomal recessive type 49 (DFNB49). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO21523 | MARVELD2 Knockout cell line (HeLa) | Human | MARVELD2 | 1:3~1:6 | Negative | Online Inquiry |
KO21524 | MARVELD2 Knockout cell line (HCT 116) | Human | MARVELD2 | 1:2~1:4 | Negative | Online Inquiry |
KO21525 | MARVELD2 Knockout cell line (HEK293) | Human | MARVELD2 | 1:3~1:6 | Negative | Online Inquiry |
KO21526 | MARVELD2 Knockout cell line (A549) | Human | MARVELD2 | 1:3~1:4 | Negative | Online Inquiry |
MARVELD2 Gene Knockout Cell Lines are specifically engineered cellular models designed to facilitate the study of the MARVELD2 gene’s function through targeted gene disruption. Using advanced CRISPR-Cas9 gene-editing technology, these cell lines exhibit a complete knockout of the MARVELD2 gene, enabling researchers to explore the gene’s role in cellular processes and disease mechanisms without the confounding effects of its normal expression.
These knockout cell lines provide a powerful tool for understanding the biological significance of MARVELD2 in various contexts, such as epithelial cell biology and cancer research. By eliminating the expression of this specific gene, users can effectively assess the subsequent phenotypic changes, signaling pathways, and cellular interactions that are impacted, thus leading to valuable insights into not only fundamental biological processes but also potential therapeutic targets for diseases where MARVELD2 plays a pivotal role.
The scientific importance of MARVELD2 Gene Knockout Cell Lines extends into both research and clinical applications. With the capability to generate reproducible data regarding gene function, these cell lines stand out for their reliability, which is critical in preclinical drug development and gene therapy studies. Compared to traditional knockout models, such as those utilizing homologous recombination, the use of CRISPR/Cas9 technology ensures a more efficient and precise gene disruption, significantly reducing the time and resources required for model development and validation.
Researchers and clinicians will find these cell lines particularly valuable due to their adaptability and ease of use in high-throughput screening, functional assays, and mechanistic studies. The substantial time savings and improved accuracy provided by these models present a compelling advantage in accelerating research outputs and refining therapeutic strategies.
At [Your Company Name], we possess extensive expertise in cell line development and gene editing technologies, resulting in a robust portfolio of high-quality biological products designed to support innovative research and clinical initiatives. Our commitment to advancing scientific inquiry and providing exceptional support ensures that users gain maximum value from our MARVELD2 Gene Knockout Cell Lines.
Please note that all services are for research use only. Not intended for any clinical use.
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