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MARCHF8 Knockout Cell Lines

Gene: MARCHF8

Official Full Name: membrane associated ring-CH-type finger 8provided by HGNC

Gene Summary: MARCH8 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH8 induces the internalization of several membrane glycoproteins (Goto et al., 2003 [PubMed 12582153]; Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Apr 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO27583 MARCHF8 Knockout cell line (HeLa) Human MARCHF8 1:3~1:6 Negative Online Inquiry
KO27584 MARCHF8 Knockout cell line (HCT 116) Human MARCHF8 1:2~1:4 Negative Online Inquiry
KO27585 MARCHF8 Knockout cell line (HEK293) Human MARCHF8 1:3~1:6 Negative Online Inquiry
KO27586 MARCHF8 Knockout cell line (A549) Human MARCHF8 1:3~1:4 Negative Online Inquiry

Background

MARCHF8 Gene Knockout Cell Lines represent a precise and innovative tool for studying the functional role of the MARCHF8 gene in both cellular and molecular biology contexts. These cell lines have undergone targeted gene editing to create a knockout model, allowing for the investigation of MARCHF8’s involvement in various biological processes, including immune response modulation and virus-host interactions. Through the utilization of CRISPR/Cas9 or similar gene-editing techniques, researchers are provided with an effective platform to explore the gene's regulatory mechanisms and its contributions to disease states.

The key functions of MARCHF8 are elucidated through its role as an E3 ubiquitin ligase, which is critical in protein degradation and endosomal sorting. By knocking out the MARCHF8 gene, researchers can systematically assess its impact on signaling pathways, cellular proliferation, apoptosis, and immune activation. This makes the MARCHF8 Gene Knockout Cell Lines invaluable for studying oncogenic processes, autoimmune conditions, and innate immune pathways, delivering insights that are crucial for developing targeted therapeutics.

From a scientific perspective, these cell lines offer enhanced specificity and consistent performance compared to other models which may lack the same degree of targeted gene alteration. The use of MARCHF8 knockout lines also facilitates reproducibility in experiments and provides clarity in interpreting the role of MARCHF8 in various contexts.

For researchers and clinicians engaged in basic or translational research, the MARCHF8 Gene Knockout Cell Lines represent a significant asset that can lead to breakthroughs in understanding complex biological systems. They deliver reliable data that can inform the design of novel therapies and broaden the scope of research in critical areas like immunology and cancer biology.

Our company is committed to advancing scientific discovery and innovation through high-quality biological products. With extensive expertise in gene-editing technologies and a focus on providing reliable research tools, we empower researchers with the necessary resources to push the boundaries of their scientific inquiries.

Please note that all services are for research use only. Not intended for any clinical use.

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