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MARCHF7 Knockout Cell Lines

Gene: MARCHF7

Official Full Name: membrane associated ring-CH-type finger 7provided by HGNC

Gene Summary: MARCH7 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments (Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Mar 2010]

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Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO16330 MARCHF7 Knockout cell line (HeLa) Human MARCHF7 1:3~1:6 Negative Online Inquiry
KO16331 MARCHF7 Knockout cell line (HCT 116) Human MARCHF7 1:2~1:4 Negative Online Inquiry
KO16332 MARCHF7 Knockout cell line (HEK293) Human MARCHF7 1:3~1:6 Negative Online Inquiry
KO16333 MARCHF7 Knockout cell line (A549) Human MARCHF7 1:3~1:4 Negative Online Inquiry

Background

MARCHF7 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to lack the MARCHF7 gene, which encodes for a membrane-associated RING-CH finger protein involved in various cellular processes, including immune response regulation and protein degradation pathways. By utilizing CRISPR-Cas9 technology for precise gene editing, these knockout cell lines facilitate in-depth study into the functional role of MARCHF7, enabling researchers to delineate its significance in normal cellular functions and pathological conditions.

The MARCHF7 knockout mechanism operates through the introduction of targeted double-strand breaks at the gene's locus, leading to insertions or deletions that disrupt the reading frame. This results in loss-of-function mutations, enabling the characterization of biological behaviors associated with MARCHF7 deficiency, such as altered cell signaling, immune evasion, and potential implications in oncogenesis. The scientific importance of these cell lines extends to applications in basic research, drug discovery, and therapeutic targeting—key areas where understanding gene function is paramount.

Unlike conventional wild-type cell lines, MARCHF7 Gene Knockout Cell Lines offer unique advantages by providing a clear model for studying gene-specific effects without the interference of MARCHF7. Researchers benefit from reproducible and reliable results that contribute to enhanced understanding of disease mechanisms and potential therapeutic strategies. Moreover, these knockout lines allow for the exploration of compensatory pathways and broader signaling networks in its absence, opening avenues for innovative approaches in cancer immunotherapy and other fields.

Investing in MARCHF7 Gene Knockout Cell Lines not only facilitates cutting-edge research but also demonstrates our commitment to providing high-quality biological products. Backed by our team's extensive expertise in gene editing and cell biology, we ensure that these engineered cell lines meet the rigorous standards required for both academic and clinical research applications. Discover how MARCHF7 Gene Knockout Cell Lines can accelerate your research endeavors and contribute to the advancement of personalized medicine.

Please note that all services are for research use only. Not intended for any clinical use.

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