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MARCHF3 Knockout Cell Lines

Gene: MARCHF3

Official Full Name: membrane associated ring-CH-type finger 3provided by HGNC

Gene Summary: This gene encodes a member of the membrane-associated RING-CH (MARCH) family. The encoded protein is an E3 ubiquitin-protein ligase that may be involved in regulation of the endosomal transport pathway. [provided by RefSeq, Mar 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO30645 MARCHF3 Knockout cell line (HeLa) Human MARCHF3 1:3~1:6 Negative Online Inquiry
KO30646 MARCHF3 Knockout cell line (HCT 116) Human MARCHF3 1:2~1:4 Negative Online Inquiry
KO30647 MARCHF3 Knockout cell line (HEK293) Human MARCHF3 1:3~1:6 Negative Online Inquiry
KO30648 MARCHF3 Knockout cell line (A549) Human MARCHF3 1:3~1:4 Negative Online Inquiry

Background

MARCHF3 Gene Knockout Cell Lines are specialized cellular models engineered to lack the expression of the MARCHF3 gene, which plays a pivotal role in the regulation of immune responses and protein trafficking. Through the application of CRISPR-Cas9 technology, these cell lines have been precisely modified to facilitate in-depth studies of the biological functions and pathological implications of MARCHF3 deficiency. The knockout mechanism allows researchers to observe the consequences of gene loss on various cellular processes, including signal transduction, endocytosis, and immune modulation.

Functionally, MARCHF3 is known to ubiquitinate target proteins, thereby influencing their stability and cellular localization. By using MARCHF3 Gene Knockout Cell Lines, scientists can elucidate the downstream effects of this ubiquitination, providing insights into its role in immune system functioning and its contribution to diseases such as autoimmune disorders and cancer. The versatility of these knockout models makes them invaluable for both basic research and translational studies aimed at developing targeted therapies and biopharmaceuticals.

A significant advantage of using MARCHF3 Gene Knockout Cell Lines is their heightened specificity in studying the gene's function without the confounding effects associated with overexpression systems or incomplete knockdowns. Compared to traditional methods, these knockout lines ensure more robust and reproducible results, allowing for streamlined experimental designs and enhanced data reliability.

For researchers and clinicians focused on advancing the understanding of immune mechanisms and developing novel therapeutic strategies, MARCHF3 Gene Knockout Cell Lines offer a valuable platform. They empower users to dissect the intricate roles of MARCHF3 in cellular contexts, fostering innovative discoveries that can lead to impactful clinical applications.

At our company, we pride ourselves on providing high-quality, rigorously validated biological products. With our expertise in gene editing technologies and cell line development, we are committed to supporting the research community with tools that drive scientific advancement.

Please note that all services are for research use only. Not intended for any clinical use.

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