Home / MAPKBP1 Knockout Cell Lines

MAPKBP1 Knockout Cell Lines

Gene: MAPKBP1

Official Full Name: mitogen-activated protein kinase binding protein 1provided by HGNC

Gene Summary: This gene encodes a scaffold protein that regulates the JNK (c-Jun N-terminal kinase) and NOD2 (nucleotide-binding oligomerization domain-containing protein 2) signaling pathways. The encoded protein interacts with another related JNK pathway scaffold protein, WDR62, via a conserved dimerization domain, and enhances JNK signaling. This protein may play a role in bacterial immunity by binding to the NOD2 receptor and negatively regulating downstream antibacterial and pro-inflammatory signaling. Mutations in this gene that impair cellular localization of the encoded protein cause a form of nephronophthisis, an autosomal-recessive kidney disorder, in human patients. [provided by RefSeq, May 2017]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO30030 MAPKBP1 Knockout cell line (HeLa) Human MAPKBP1 1:3~1:6 Negative Online Inquiry
KO30031 MAPKBP1 Knockout cell line (HCT 116) Human MAPKBP1 1:2~1:4 Negative Online Inquiry
KO30032 MAPKBP1 Knockout cell line (HEK293) Human MAPKBP1 1:3~1:6 Negative Online Inquiry
KO30033 MAPKBP1 Knockout cell line (A549) Human MAPKBP1 1:3~1:4 Negative Online Inquiry

Background

MAPKBP1 Gene Knockout Cell Lines are specifically engineered cellular models that exhibit targeted deletion of the MAPKBP1 gene, an important regulator involved in various cellular signaling pathways, including stress response and proliferation. These knockout cell lines are invaluable tools in biological research, allowing scientists to investigate the role of MAPKBP1 in cellular mechanics, disease models, and therapeutic responses.

The primary function of these knockout cell lines is to facilitate in-depth studies on the signaling pathways influenced by MAPKBP1. By eliminating the expression of this gene, researchers can observe the resultant phenotypic changes, including alterations in cell cycle regulation, apoptosis, and responses to environmental stressors. The underlying mechanism involves the disruption of normal gene function, enabling the examination of compensatory pathways and identification of novel targets for therapeutic intervention.

MAPKBP1 gene knockout cell lines hold significant scientific importance in both research and clinical settings, particularly in oncology and developmental biology. Their utility extends to drug discovery, where understanding the function of MAPKBP1 can aid in the identification of potential anti-cancer agents. Furthermore, these cell lines allow for the exploration of genetic interactions and the development of personalized medicine approaches.

What sets MAPKBP1 Gene Knockout Cell Lines apart from alternative models is their specificity and ease of use. Unlike traditional knockdown methods that may only partially inhibit gene function, these knockout lines provide a robust and stable genetic modification. This ensures reproducibility and reliability in experimental outcomes, which are critical for publishing discoveries and advancing scientific understanding.

For researchers and clinicians, these cell lines present an exceptional opportunity to unlock the complexities of cellular behavior and the roles of specific genes in health and disease. By providing hotbed environments for experimentation, MAPKBP1 Gene Knockout Cell Lines empower the scientific community to pave the way for novel diagnostics and therapeutics.

As a leader in biological product offerings, our company is committed to providing high-quality research tools designed to support groundbreaking scientific advancements. Our expertise ensures that every product meets stringent quality standards, delivering reliability and performance crucial for superior research outcomes.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.