Gene: MAPK7
Official Full Name: mitogen-activated protein kinase 7provided by HGNC
Gene Summary: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
GP00555 | MAPK7 gRNA5-gRNA6 KO plasmid | MAPK7 | $850 | |||
GP00634 | MAPK7 gRNA1-gRNA2 KO plasmid | MAPK7 | $850 | |||
KO00808 | MAPK7 Knockout cell line (HeLa) | Human | MAPK7 | 1:3~1:6 | Negative | Online Inquiry |
KO10650 | MAPK7 Knockout cell line (HCT 116) | Human | MAPK7 | 1:2~1:4 | Negative | Online Inquiry |
KO10651 | MAPK7 Knockout cell line (HEK293) | Human | MAPK7 | 1:3~1:6 | Negative | Online Inquiry |
KO10652 | MAPK7 Knockout cell line (A549) | Human | MAPK7 | 1:3~1:4 | Negative | Online Inquiry |
MAPK7 Gene Knockout Cell Lines are engineered cellular models specifically designed to investigate the functions and biological pathways associated with the MAPK7 gene, also known as ERK5. These knockout cell lines are generated through the use of advanced gene-editing techniques such as CRISPR-Cas9, resulting in the complete disruption of the MAPK7 gene. This precise gene editing allows researchers to study the physiological and pathological roles of MAPK7 in various contexts, including cellular growth, differentiation, and response to stress.
Functionally, MAPK7 plays a significant role in signaling pathways that are crucial for cellular responses to external signals. Its deletion offers insights into not only normal cellular processes but also how aberrations in MAPK signaling contribute to diseases such as cancer and neurodegeneration. By using these knockout cell lines, researchers can elucidate the downstream effects of MAPK7 absence on critical cellular functions, thereby advancing our understanding of numerous disease mechanisms.
The scientific importance of MAPK7 Gene Knockout Cell Lines extends to both basic research and clinical applications. They serve as powerful tools for drug discovery, toxicity testing, and biomarker identification, particularly in pharmacological studies aiming to target MAPK signaling pathways. Compared to other experimental models, these knockout lines provide a more accurate representation of the physiological condition, making findings more translatable to human health outcomes.
A key advantage of MAPK7 Gene Knockout Cell Lines lies in their specificity and reproducibility. These cell lines are rigorously validated to ensure that the knockout is effective and consistent, giving researchers confidence in their results. Furthermore, they present a cost-effective alternative to more complex animal models, enabling more rapid and scalable research.
For researchers and clinicians seeking to expand their understanding of MAPK pathways, the MAPK7 Gene Knockout Cell Lines are invaluable. They not only facilitate investigations into the fundamental biology of MAPK7 but also support the translational aspects of research aimed at developing targeted therapeutics.
With a commitment to advancing biological sciences, our company offers these knockout cell lines alongside a suite of other innovative cellular models, ensuring that researchers have access to cutting-edge tools for their studies. Our expertise in genetic engineering and cellular biology equips us to support the scientific community in achieving breakthroughs across various fields.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.