Gene: MAP3K12
Official Full Name: mitogen-activated protein kinase kinase kinase 12provided by HGNC
Gene Summary: This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.[provided by RefSeq, Jul 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO10702 | MAP3K12 Knockout cell line (HeLa) | Human | MAP3K12 | 1:3~1:6 | Negative | Online Inquiry |
KO10703 | MAP3K12 Knockout cell line (HCT 116) | Human | MAP3K12 | 1:2~1:4 | Negative | Online Inquiry |
KO10704 | MAP3K12 Knockout cell line (HEK293) | Human | MAP3K12 | 1:3~1:6 | Negative | Online Inquiry |
KO10705 | MAP3K12 Knockout cell line (A549) | Human | MAP3K12 | 1:3~1:4 | Negative | Online Inquiry |
MAP3K12 Gene Knockout Cell Lines represent a pivotal advancement in the field of molecular biology and genetics, providing researchers with invaluable tools for studying the functional roles of the MAP3K12 gene. These engineered cell lines are generated through precise genetic modification techniques, ensuring the complete ablation of the MAP3K12 gene. This specific knockout allows for the examination of cellular signaling pathways, particularly those involved in stress responses and apoptosis, enabling researchers to dissect the complexities of MAP3K12-related biological processes.
The key function of the MAP3K12 Gene Knockout Cell Lines lies in their utility for experimental investigations into signal transduction pathways linked to cellular differentiation, immune responses, and oncogenic processes. By removing the MAP3K12 gene, these cell lines serve as essential models for understanding the mechanisms whereby aberrations in this gene can lead to various pathophysiological conditions. Researchers can explore the downstream effects of MAP3K12 signaling, making these cell lines instrumental for drug discovery and therapeutic development.
In scientific and clinical settings, the MAP3K12 Gene Knockout Cell Lines are critical for researchers focused on cancer biology, immunology, and therapeutic interventions. The specificity of gene knockout allows for clearer interpretations of experimental data, reducing noise from confounding factors that often plague traditional methodologies.
What sets these knockout cell lines apart from alternative products on the market is their high degree of specificity and reliability, underpinned by rigorously validated gene-targeting technologies. Additionally, they come with a comprehensive supporting dataset that includes characterization details and suggested application protocols, making them an efficient choice for busy laboratories.
For researchers and clinicians engaged in the exploration of signal transduction pathways and cellular responses, the MAP3K12 Gene Knockout Cell Lines provide a unique opportunity to gain deeper insights. The ability to dynamically assess gene function within controlled experimental conditions presents significant advantages in understanding complex biological systems.
With extensive experience in the development and production of genetically modified cell lines, our company is committed to delivering quality research tools that empower scientists worldwide to advance their discoveries. Our unwavering dedication to innovation and scientific excellence ensures that our products meet the highest standards in research applications.
Please note that all services are for research use only. Not intended for any clinical use.
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