Gene: MAP1LC3C
Official Full Name: microtubule associated protein 1 light chain 3 gammaprovided by HGNC
Gene Summary: Autophagy is a highly regulated bulk degradation process that plays an important role in cellular maintenance and development. MAP1LC3C is an ortholog of the yeast autophagosome protein Atg8 (He et al., 2003 [PubMed 12740394]).[supplied by OMIM, Nov 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO08426 | MAP1LC3C Knockout cell line (HEK293) | Human | MAP1LC3C | 1:3~1:6 | Negative | Online Inquiry |
MAP1LC3C Gene Knockout Cell Lines are specialized biological tools designed to study the essential roles of the MAP1LC3C gene in cellular processes. These cell lines are engineered to lack the MAP1LC3C gene, a crucial component of the cellular autophagy machinery, which is involved in the degradation and recycling of cellular components. By removing this gene, researchers can investigate the impacts on autophagy, protein degradation, and cellular homeostasis, facilitating a deeper understanding of both normal physiological processes and pathological conditions such as neurodegenerative diseases and cancer.
The key function of MAP1LC3C lies in its role in autophagosome formation, where it aids in the encapsulation of dysfunctional cellular components for lysosomal degradation. The knockout of this gene alters cellular responses to stress and impacts nutrient sensing pathways, thereby offering insights into how dysregulation can lead to disease. Researchers utilize these cell models to perform high-throughput screening, investigate therapeutic compounds, and understand gene function through various molecular assays.
In the realm of scientific importance, MAP1LC3C knockout cell lines serve as invaluable tools in both basic and translational research. They allow scientists to manipulate and monitor autophagic processes in real-time, fostering advancements in drug discovery and therapeutic interventions, particularly targeting metabolic and neurodegenerative disorders.
What sets MAP1LC3C knockout cell lines apart is their specificity and reliability compared to other genetic manipulation techniques, such as CRISPR or traditional siRNA methods. These established cell lines come pre-validated, significantly reducing the time and resources typically required for experimentation while ensuring reproducibility of results.
For researchers and clinicians, the unparalleled value of these cell lines lies in their potential to uncover new therapeutic targets and elucidate disease mechanisms in a controlled environment. This capability can accelerate the translation of discoveries from bench to bedside.
Our company is committed to providing high-quality biological products that empower researchers and clinicians in their quest to better understand cellular processes and ultimately improve patient outcomes. We leverage extensive expertise in genetic engineering and cell biology to offer innovative solutions tailored to the needs of the life sciences community.
Please note that all services are for research use only. Not intended for any clinical use.
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