Gene: MAML3
Official Full Name: mastermind like transcriptional coactivator 3provided by HGNC
Gene Summary: Enables transcription coactivator activity. Involved in Notch signaling pathway and positive regulation of transcription by RNA polymerase II. Located in nuclear speck. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO16368 | MAML3 Knockout cell line (HeLa) | Human | MAML3 | 1:3~1:6 | Negative | Online Inquiry |
KO16369 | MAML3 Knockout cell line (HEK293) | Human | MAML3 | 1:3~1:6 | Negative | Online Inquiry |
KO16370 | MAML3 Knockout cell line (A549) | Human | MAML3 | 1:3~1:4 | Negative | Online Inquiry |
MAML3 Gene Knockout Cell Lines are genetically engineered cell lines designed to specifically disrupt the MAML3 gene, a key player in the Notch signaling pathway which is critical for cellular communication, differentiation, and many developmental processes. By creating a knockout model for MAML3, researchers can investigate the gene's role in various biological contexts, including its contributions to oncogenesis, stem cell biology, and tissue regeneration.
These cell lines function through CRISPR-Cas9 gene-editing technology, which allows for precise deletions or modifications in the genomic sequence. Once the MAML3 gene is knocked out, the resulting phenotypic and molecular changes serve as a powerful tool to elucidate the biological functions attributed to this gene. Researchers benefit from a clear, controllable model system that provides insights into how loss of MAML3 impacts cellular behavior, ultimately aiding in the discovery of novel therapeutic targets.
The scientific importance of MAML3 Gene Knockout Cell Lines extends to both fundamental research and clinical applications. They are invaluable in studying various diseases where Notch signaling is implicated, such as cancer, neurodegeneration, and cardiovascular diseases. By promoting a deeper understanding of the MAML3 gene, researchers can pave the way for advancements in drug development and targeted therapies that could improve patient outcomes.
One of the standout advantages of our MAML3 Gene Knockout Cell Lines is their ease of use and reliability. Unlike other knockout methodologies that may lead to off-target effects or variable results, our product ensures high specificity and consistency. Furthermore, they come with detailed characterization data that allow for immediate application in experimental designs, saving valuable time and resources.
For researchers, clinicians, and biotechnologists, the value of MAML3 Gene Knockout Cell Lines lies in their capacity to facilitate significant discoveries in gene function that can translate into real-world medical therapies. With specific focus on enhancing experimental models, our company prides itself on providing cutting-edge products grounded in rigorous scientific research and innovation, empowering the next generation of breakthroughs in biomedical science.
Please note that all services are for research use only. Not intended for any clinical use.
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