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MAGI1 Knockout Cell Lines

Gene: MAGI1

Official Full Name: membrane associated guanylate kinase, WW and PDZ domain containing 1provided by HGNC

Gene Summary: The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell-cell contact. The product of this gene may play a role as scaffolding protein at cell-cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO10227 MAGI1 Knockout cell line (HeLa) Human MAGI1 1:3~1:6 Negative Online Inquiry
KO10228 MAGI1 Knockout cell line (HCT 116) Human MAGI1 1:2~1:4 Negative Online Inquiry
KO10229 MAGI1 Knockout cell line (HEK293) Human MAGI1 1:3~1:6 Negative Online Inquiry
KO10230 MAGI1 Knockout cell line (A549) Human MAGI1 1:3~1:4 Negative Online Inquiry

Background

MAGI1 Gene Knockout Cell Lines are genetically engineered cell models specifically designed to provide researchers with insights into the functional role of the MAGI1 (Membrane Associated Guanylate Kinase Inverted 1) gene. By employing CRISPR/Cas9 technology, these cell lines exhibit a complete knockout of the MAGI1 gene, allowing for the study of its contributions to cell signaling, tumorigenesis, and cellular adhesion processes.

The MAGI1 protein is critically involved in multiple molecular interactions, particularly those related to the regulation of intracellular signaling pathways and the structural organization of cell junctions. The knockout mechanism allows researchers to observe the phenotypic consequences resulting from loss of MAGI1 expression, enabling deeper investigations into its role in cancer progression and neurodevelopmental disorders. This function is crucial as it aids in understanding the molecular underpinnings of diseases where MAGI1 dysregulation is implicated.

The scientific importance of MAGI1 Gene Knockout Cell Lines extends to both research and clinical applications, including drug discovery, biomarker validation, and functional genomic studies. By facilitating high-throughput screening of potential therapeutic agents targeting MAGI1-related pathways, these cell lines serve as valuable tools for identifying new treatment strategies and elucidating the pathophysiology of related diseases.

What sets our MAGI1 Gene Knockout Cell Lines apart from alternative models is their unparalleled specificity and reliability, allowing researchers to generate reproducible results essential for translational research. Additionally, our products are validated through rigorous characterization processes, ensuring that they maintain genetic integrity and functional quality.

For researchers and clinicians seeking to unlock the therapeutic potential of MAGI1-related research, these knockout cell lines present a quintessential resource. Our commitment to quality and innovation in biological products is reflected in our expertise and dedication to advancing scientific inquiry. Partner with us to enhance your research capabilities and drive forward the next generation of scientific discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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