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MAGED2 Knockout Cell Lines

Gene: MAGED2

Official Full Name: MAGE family member D2provided by HGNC

Gene Summary: This gene is a member of the MAGED gene family. The MAGED genes are clustered on chromosome Xp11. This gene is located in Xp11.2, a hot spot for X-linked intellectual disability (XLID). Mutations in this gene cause a form of transient antenatal Bartter's syndrome. This gene may also be involved in several types of cancer, including breast cancer and melanoma. The protein encoded by this gene is progressively recruited from the cytoplasm to the nucleoplasm during the interphase and after nucleolar stress and is thus thought to play a role in cell cycle regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO31421 MAGED2 Knockout cell line (HeLa) Human MAGED2 1:3~1:6 Negative Online Inquiry
KO31422 MAGED2 Knockout cell line (HCT 116) Human MAGED2 1:2~1:4 Negative Online Inquiry
KO31423 MAGED2 Knockout cell line (HEK293) Human MAGED2 1:3~1:6 Negative Online Inquiry
KO31424 MAGED2 Knockout cell line (A549) Human MAGED2 1:3~1:4 Negative Online Inquiry

Background

MAGED2 Gene Knockout Cell Lines represent a cutting-edge biological tool engineered to facilitate the functional study of the MAGED2 gene, a member of the MAGE gene family that plays critical roles in various cellular processes, including cell proliferation and apoptosis. These knockout cells have been meticulously developed using CRISPR-Cas9 technology, which enables precise editing of the MAGED2 locus, effectively disrupting its expression.

The key function of MAGED2 Gene Knockout Cell Lines lies in their ability to provide researchers with a model system to investigate the consequences of MAGED2 loss-of-function at both the molecular and phenotypic levels. The mutation of this gene allows for the assessment of its role in human diseases, particularly in cancer biology, where MAGED2 is implicated in tumor development and progression. By using these cell lines, researchers can elucidate the pathways affected by MAGED2 and identify potential therapeutic targets.

The scientific importance of these cell lines extends to both research and clinical settings, offering a platform for drug testing and the evaluation of gene therapies. With their controlled genetic profile, these knockout cell lines enable researchers to conduct high-throughput screening and detailed mechanistic studies, ultimately translating into improved understanding of disease mechanisms and efficacy for novel treatments.

A significant advantage of MAGED2 Gene Knockout Cell Lines over traditional models is their robust reproducibility and ease of use, reducing variability in experimental outcomes. Furthermore, the CRISPR-Cas9 gene editing method minimizes off-target effects, ensuring that observed phenotypes can be attributed to the intended genetic modification.

For researchers and clinicians striving to advance their understanding of gene function and disease, MAGED2 Gene Knockout Cell Lines provide an unparalleled resource that is tailored to meet the complexities of modern biological research. Our company, recognized for its commitment to delivering high-quality biological products, stands behind this innovative tool, empowering the scientific community to pave the way for breakthroughs in gene function analysis and therapeutic interventions.

Please note that all services are for research use only. Not intended for any clinical use.

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