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MAGEB1 Knockout Cell Lines

Gene: MAGEB1

Official Full Name: MAGE family member B1provided by HGNC

Gene Summary: This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. This gene is localized in the DSS (dosage-sensitive sex reversal) critical region, and expressed in testis and in a significant fraction of tumors of various histological types. This gene and other MAGEB members are clustered on chromosome Xp22-p21. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene, however, the full length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]

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Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO36727 MAGEB1 Knockout cell line (HCT 116) Human MAGEB1 1:2~1:4 Negative Online Inquiry

Background

MAGEB1 Gene Knockout Cell Lines are genetically engineered cell lines in which the MAGEB1 gene has been selectively disrupted or knocked out. This strategic modification allows researchers to study the biological roles and functions of MAGEB1 in various cellular processes like cancer progression, immune response, and cell differentiation. The knockout mechanism is typically facilitated through CRISPR/Cas9 technology, which enables precise alterations in the genomic sequence, thus providing valuable insights into gene function.

These cell lines serve a crucial role in both fundamental and applied research, particularly within oncology and immunology. By providing a controlled model for the absence of MAGEB1, scientists can investigate how its loss affects tumor behavior, susceptibility to therapies, and the activation of immune cells. Such studies that leverage these knockout cell lines aid in the development of targeted therapies and personalized medicine approaches aimed at enhancing treatment efficacy.

One of the key advantages of MAGEB1 Gene Knockout Cell Lines compared to traditional knockout methods is the precision and efficiency of the CRISPR/Cas9 system, which minimizes off-target effects and allows for a reproducible setup. Furthermore, these cell lines can be utilized in high-throughput screening applications, making them indispensable tools for drug discovery and therapeutic development.

Researchers and clinicians will find this product particularly beneficial as it aids in elucidating the complex role of MAGEB1 in disease pathology while potentially speeding up the translational process from bench to bedside. The ability to fully comprehend the implications of MAGEB1 disruption opens new avenues for developing innovative treatment strategies.

With extensive expertise in genetic engineering and a commitment to advancing biomedical research, our company is dedicated to providing high-quality products like MAGEB1 Gene Knockout Cell Lines that empower researchers in their quest for scientific discovery and transformative clinical applications.

Please note that all services are for research use only. Not intended for any clinical use.

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