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MAGEA11 Knockout Cell Lines

Gene: MAGEA11

Official Full Name: MAGE family member A11provided by HGNC

Gene Summary: This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO36739 MAGEA11 Knockout cell line (HeLa) Human MAGEA11 1:3~1:6 Negative Online Inquiry

Background

MAGEA11 gene knockout cell lines represent a significant advancement in the field of molecular biology. These engineered cell lines have been meticulously designed to completely eliminate the expression of the MAGEA11 gene, a member of the MAGE (Melanoma Antigen Gene) family, which plays a crucial role in various biological processes, including tumorigenesis and immune response modulation. The knockout mechanism is achieved through innovative CRISPR-Cas9 technology, allowing for precise genomic editing and a reliable model for studying gene function.

The key function of MAGEA11 gene knockout cell lines lies in their ability to serve as a vital tool for understanding the implications of MAGEA11 in cancer biology. By enabling researchers to investigate the phenotypic consequences of gene deletion, these cell lines facilitate the exploration of pathways involved in tumor formation, progression, and the response to immunotherapy. Furthermore, they lay the groundwork for the development of targeted treatments aimed at inhibiting the MAGEA11 protein, providing profound insights into potential therapeutic strategies.

In a landscape that often relies on conventional cell lines, MAGEA11 gene knockout models present distinct advantages. Unlike standard models, these specialized lines significantly reduce background noise associated with gene expression variability, allowing for more reproducible and interpretable results. This precision renders them invaluable for both fundamental research and translational studies into novel cancer therapies.

For researchers, clinicians, and pharmaceutical companies, the implications of harnessing MAGEA11 knockout cell lines are substantial. They not only open avenues for elucidating cancer mechanisms but also enhance the prospects for advancing personalized medicine. Our company is dedicated to providing high-quality biological products, and our MAGEA11 gene knockout cell lines are a testament to our commitment to facilitating cutting-edge research that accelerates discoveries in the life sciences. By choosing our product, you are equipping your laboratory with a nuanced tool essential for pioneering investigations into the complexities of cancer biology.

Please note that all services are for research use only. Not intended for any clinical use.

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