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MAF Knockout Cell Lines

Gene: MAF

Official Full Name: MAF bZIP transcription factorprovided by HGNC

Gene Summary: The protein encoded by this gene is a DNA-binding, leucine zipper-containing transcription factor that acts as a homodimer or as a heterodimer. Depending on the binding site and binding partner, the encoded protein can be a transcriptional activator or repressor. This protein plays a role in the regulation of several cellular processes, including embryonic lens fiber cell development, increased T-cell susceptibility to apoptosis, and chondrocyte terminal differentiation. Defects in this gene are a cause of juvenile-onset pulverulent cataract as well as congenital cerulean cataract 4 (CCA4). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO02528 MAF Knockout cell line (HEK293) Human MAF 1:3~1:6 Negative Online Inquiry

Background

MAF Gene Knockout Cell Lines are a cutting-edge biological tool designed specifically for the study of the MAF gene and its associated pathways. These cell lines have been meticulously engineered to contain targeted deletions of the MAF gene, allowing researchers to explore the gene's function, regulation, and implications in various cellular processes. By removing the gene's expression, these cell lines enable scientists to observe resultant phenotypic changes and alterations in signaling pathways, thus elucidating the role of MAF in transcription regulation, immune response, and oncogenesis.

The primary mechanism of action involves the CRISPR-Cas9 gene-editing technology, which introduces double-strand breaks in the genomic DNA, thereby facilitating the precise knockout of the MAF gene. Once generated, these knockout cell lines serve as invaluable models for studying the consequences of MAF loss, providing insights into its involvement in diseases such as cancer and metabolic disorders. The ability to manipulate and analyze these cell lines accelerates research in gene function and opens new avenues for therapeutic discovery.

The scientific importance of MAF Gene Knockout Cell Lines extends to both basic research and clinical applications. They are vital for understanding MAF's role in cellular differentiation, immune modulation, and stress responses, making them essential tools in the fields of cancer biology and immunology. Researchers can leverage these cell lines to identify novel therapeutic targets and evaluate the efficacy of potential drugs.

One of the standout advantages of MAF Gene Knockout Cell Lines is their specificity, efficiency, and reproducibility, which often surpasses existing models that rely on pharmacological inhibitors or non-targeted RNA interference techniques. Moreover, these cell lines can be easily adapted to various culture conditions and experimental setups, enhancing their utility across multiple research disciplines.

For researchers and clinicians dedicated to advancing our understanding of gene function and exploring innovative treatments, MAF Gene Knockout Cell Lines present a compelling choice due to their ability to deliver precise and actionable insights. Our company excels in providing high-quality, expertly curated biological products and technologies that empower researchers to push the boundaries of science, making discoveries that improve health outcomes and drive the future of medicine.

Please note that all services are for research use only. Not intended for any clinical use.

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