Gene: MACROH2A1
Official Full Name: macroH2A.1 histoneprovided by HGNC
Gene Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO05736 | MACROH2A1 Knockout cell line (HeLa) | Human | MACROH2A1 | 1:3~1:6 | Negative | Online Inquiry |
KO05737 | MACROH2A1 Knockout cell line (HCT 116) | Human | MACROH2A1 | 1:2~1:4 | Negative | Online Inquiry |
KO05738 | MACROH2A1 Knockout cell line (HEK293) | Human | MACROH2A1 | 1:3~1:6 | Negative | Online Inquiry |
KO05739 | MACROH2A1 Knockout cell line (A549) | Human | MACROH2A1 | 1:3~1:4 | Negative | Online Inquiry |
MACROH2A1 Gene Knockout Cell Lines are specialized cell lines engineered to lack the expression of the MACROH2A1 histone variant. This product serves as an essential tool for researchers studying epigenetic regulation and its implications in cellular processes and disease mechanisms. The knockout of the MACROH2A1 gene disrupts normal chromatin remodeling, enabling scientists to investigate the functional roles of this variant in processes such as gene expression, DNA repair, and chromatin organization.
The key mechanism through which MACROH2A1 influences cellular functions is its role in modulating chromatin structure and accessibility. By altering the histone landscape, MACROH2A1 impacts transcriptional regulation and facilitates various epigenetic modifications that are significant for maintaining cellular homeostasis. As such, these knockout cell lines provide a unique platform for exploring the consequences of disrupted epigenetic regulation, making them invaluable in both basic and translational research.
In the context of scientific inquiry, MACROH2A1 gene knockout cell lines have applications in cancer research, developmental biology, and stem cell investigations. Understanding the functions of MACROH2A1 can elucidate mechanisms underpinning tumorigenesis and cellular differentiation, therefore informing therapeutic strategies in oncology and regenerative medicine.
The specific advantages of using our MACROH2A1 Gene Knockout Cell Lines include their high fidelity and reproducibility, which are critical for obtaining reliable data in sensitive experiments. Unlike alternative models, our cell lines are validated through robust characterization to ensure consistent performance, enhancing the reliability of experimental outcomes.
For researchers and clinicians engaged in epigenetics or related fields, these knockout cell lines represent a powerful resource for dissecting the complexities of gene regulation. The potential to uncover novel insights into genomic functions and disease mechanisms underscores the value they provide to the scientific community.
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Please note that all services are for research use only. Not intended for any clinical use.
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