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LZTS2 Knockout Cell Lines

Gene: LZTS2

Official Full Name: leucine zipper tumor suppressor 2provided by HGNC

Gene Summary: The protein encoded by this gene belongs to the leucine zipper tumor suppressor family of proteins, which function in transcription regulation and cell cycle control. This family member can repress beta-catenin-mediated transcriptional activation and is a negative regulator of the Wnt signaling pathway. It negatively regulates microtubule severing at centrosomes, and is necessary for central spindle formation and cytokinesis completion. It is implicated in cancer, where it may inhibit cell proliferation and decrease susceptibility to tumor development. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO24875 LZTS2 Knockout cell line (HeLa) Human LZTS2 1:3~1:6 Negative Online Inquiry
KO24876 LZTS2 Knockout cell line (HCT 116) Human LZTS2 1:2~1:4 Negative Online Inquiry
KO24877 LZTS2 Knockout cell line (HEK293) Human LZTS2 1:3~1:6 Negative Online Inquiry
KO24878 LZTS2 Knockout cell line (A549) Human LZTS2 1:3~1:4 Negative Online Inquiry

Background

LZTS2 Gene Knockout Cell Lines are specialized cell lines engineered to disrupt the expression of the LZTS2 gene, a gene implicated in various cellular processes, including tumor suppression and cell cycle regulation. This innovative product serves as an invaluable tool for researchers studying the functional role of LZTS2 in both normal physiology and disease pathology.

The key function of LZTS2 Gene Knockout Cell Lines is to enable investigators to dissect the biological pathways influenced by LZTS2, thereby elucidating its contribution to cancer progression, response to therapy, and overall cellular signaling mechanisms. By utilizing CRISPR/Cas9 or similar gene-editing technologies, these cell lines provide a reliable model for studying knockdown effects, facilitating experimentation surrounding gene interactions, protein dynamics, and potential compensatory mechanisms in cellular function.

Scientific importance is underscored by the growing recognition of LZTS2's role as a tumor suppressor, linking it to breast and colorectal cancers, among others. These cell lines can be employed in various applications, such as drug screening assays, gene function studies, and the exploration of molecular mechanisms underlying oncogenesis, making them essential for both academic research and clinical translational research.

The LZTS2 Gene Knockout Cell Lines stand out against alternatives through their high specificity and reproducibility. Unlike traditional knockout cell lines that may exhibit off-target effects, our precision-engineered lines ensure targeted elimination of LZTS2, resulting in a clearer understanding of gene function. Additionally, our product is supported by comprehensive documentation and protocols, ensuring ease of use in laboratory settings.

For researchers and clinicians alike, investing in LZTS2 Gene Knockout Cell Lines translates to accelerated research timelines and more accurate modeling of human disease mechanisms. Our company, renowned for its expertise in genetic engineering and cell line development, is committed to providing cutting-edge biological tools that empower scientific discovery and enhance therapeutic innovation.

Please note that all services are for research use only. Not intended for any clinical use.

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