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LTN1 Knockout Cell Lines

Gene: LTN1

Official Full Name: listerin E3 ubiquitin protein ligase 1provided by HGNC

Gene Summary: Like most RING finger proteins, LTN1 functions as an E3 ubiquitin ligase (Chu et al., 2009 [PubMed 19196968]).[supplied by OMIM, Nov 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01484 LTN1 Knockout cell line(HeLa) Human LTN1 1:3~1:6 Negative Online Inquiry
KO16429 LTN1 Knockout cell line (HCT 116) Human LTN1 1:2~1:4 Negative Online Inquiry
KO16430 LTN1 Knockout cell line (HEK293) Human LTN1 1:3~1:6 Negative Online Inquiry
KO16431 LTN1 Knockout cell line (A549) Human LTN1 1:3~1:4 Negative Online Inquiry

Background

LTN1 Gene Knockout Cell Lines are specifically engineered cellular models that lack the functional LTN1 gene, known to play a crucial role in various cellular processes, including RNA regulation and protein homeostasis. These knockout cell lines are created using advanced techniques such as CRISPR-Cas9 gene editing, which enables precise excision of the targeted gene, thus allowing researchers to meticulously study the effects of LTN1 deficiency on cellular mechanisms.

The primary functions of LTN1 involve modulation of the ubiquitin-proteasome system, responsible for cellular protein degradation. By knocking out LTN1, researchers can investigate the resulting cellular changes, including alterations in protein stability, impacts on the stress response, and consequences for cell cycle regulation and differentiation. This model serves as a valuable tool in elucidating the gene's role in disease mechanisms, particularly in neurodegenerative disorders and certain cancers, where dysregulation of protein homeostasis is prevalent.

The scientific importance of LTN1 Gene Knockout Cell Lines is manifold, offering applications in fundamental research, drug discovery, and personalized medicine. These models empower researchers to assess drug response, explore pathways involved in disease progression, and identify potential therapeutic targets. Compared to conventional cell lines, the LTN1 knockout lines provide a more authentic system for studying gene function in a controlled environment, thereby enhancing the relevance of experimental findings.

One of the significant advantages of our product is the high reliability and reproducibility stemming from precise gene editing methodologies. These knockout lines are characterized by minimal off-target effects, ensuring that the observed phenotypes are directly attributable to the absence of the LTN1 gene. Additionally, they can be easily integrated into existing research workflows, making them an efficient choice for labs looking to advance their studies.

For researchers and clinicians alike, the LTN1 Gene Knockout Cell Lines embody an essential resource for advancing molecular biology understanding and therapeutic innovation. Our company, with extensive expertise in genetic engineering and cell line development, is dedicated to providing high-quality biological products that meet rigorous scientific standards, empowering the research community to achieve groundbreaking discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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