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LTBR Knockout Cell Lines

Gene: LTBR

Official Full Name: lymphotoxin beta receptorprovided by HGNC

Gene Summary: This gene encodes a member of the tumor necrosis factor receptor superfamily. The major ligands of this receptor include lymphotoxin alpha/beta and tumor necrosis factor ligand superfamily member 14. The encoded protein plays a role in signalling during the development of lymphoid and other organs, lipid metabolism, immune response, and programmed cell death. Activity of this receptor has also been linked to carcinogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO11057 LTBR Knockout cell line (HeLa) Human LTBR 1:3~1:6 Negative Online Inquiry
KO11058 LTBR Knockout cell line (HCT 116) Human LTBR 1:2~1:4 Negative Online Inquiry
KO11059 LTBR Knockout cell line (A549) Human LTBR 1:3~1:4 Negative Online Inquiry

Background

LTBR Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to facilitate the study of the lymphotoxin β receptor (LTBR) by enabling the complete disruption of its gene expression. These knockout cell lines are crucial tools for researchers aiming to investigate the role of LTBR in various biological processes, including immune response, inflammation, and tissue homeostasis. By providing a controlled environment where the LTBR gene is inactivated, researchers can elucidate the downstream signaling pathways and physiological consequences associated with LTBR modulation.

The key mechanism underlying these cell lines is the targeted gene editing, typically employing CRISPR/Cas9 technology to introduce specific mutations that result in the loss of function of the LTBR gene. This precise gene editing offers researchers the ability to create isogenic control lines and analyze phenotypic changes that arise from LTBR deficiency, granting unparalleled insights into its contribution to immune dysregulation, autoimmune diseases, and cancer biology.

The scientific significance of LTBR Gene Knockout Cell Lines extends beyond basic research; they serve as valuable models for preclinical studies aimed at identifying potential therapeutic targets for diseases where LTBR is implicated. Their use in drug discovery and development processes can streamline the identification of LTBR-related pharmacological agents, enhancing translation into clinical settings.

Compared to alternative models, such as transient knockdown systems or conventional knockout models, LTBR Gene Knockout Cell Lines provide enhanced stability, reproducibility, and long-term viability in culture. This stability allows for extended experimentation and more consistent results, ultimately leading to higher confidence in data interpretation.

For researchers and clinicians focused on understanding immune mechanisms and developing novel therapeutic strategies, LTBR Gene Knockout Cell Lines represent a transformative product that accelerates discovery and innovation. The ability to precisely manipulate LTBR provides a distinct advantage in cutting-edge research.

As a leader in the field of genetically modified cell line technology, our company is committed to providing high-quality, reliable biological products that empower scientists. With extensive expertise in gene editing and cellular biology, we ensure that our LTBR Gene Knockout Cell Lines meet the rigorous standards required for impactful research.

Please note that all services are for research use only. Not intended for any clinical use.

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