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LTBP4 Knockout Cell Lines

Gene: LTBP4

Official Full Name: latent transforming growth factor beta binding protein 4provided by HGNC

Gene Summary: The protein encoded by this gene binds transforming growth factor beta (TGFB) as it is secreted and targeted to the extracellular matrix. TGFB is biologically latent after secretion and insertion into the extracellular matrix, and sheds TGFB and other proteins upon activation. Defects in this gene may be a cause of cutis laxa and severe pulmonary, gastrointestinal, and urinary abnormalities. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO34188 LTBP4 Knockout cell line (HeLa) Human LTBP4 1:3~1:6 Negative Online Inquiry
KO34189 LTBP4 Knockout cell line (HCT 116) Human LTBP4 1:2~1:4 Negative Online Inquiry
KO34190 LTBP4 Knockout cell line (HEK293) Human LTBP4 1:3~1:6 Negative Online Inquiry
KO34191 LTBP4 Knockout cell line (A549) Human LTBP4 1:3~1:4 Negative Online Inquiry

Background

LTBP4 Gene Knockout Cell Lines represent a cutting-edge tool in the field of molecular biology, specifically designed to facilitate the study of the latent TGF-β binding protein 4 (LTBP4). These cell lines have been expertly engineered to contain a targeted knockout of the LTBP4 gene, leading to a comprehensive disruption of its associated biological functions. By examining these knockout models, researchers can illuminate the roles LTBP4 plays in the regulation of extracellular matrix dynamics and TGF-β signaling pathways, which are critical in various physiological and pathological contexts.

The primary function of LTBP4 involves its interaction with latent TGF-β, a key regulator of cellular processes such as proliferation, differentiation, and tissue homeostasis. In the absence of LTBP4, alterations in TGF-β activation and signaling may be elucidated, providing insights into fibrosis, cancer progression, and immune responses. These knockout cell lines are invaluable tools for studying the mechanistic underpinnings of disease states, offering researchers a unique experimental platform to probe the downstream effects of LTBP4 disruption on cell behavior.

LTBP4 Gene Knockout Cell Lines hold significant implications in both research and clinical settings. Their application extends to basic cellular biology, tumor microenvironment studies, and potential therapeutic investigations targeting TGF-β pathways. Unlike traditional overexpression or knockdown approaches, our knockout cell lines provide a more accurate representation of gene function under physiological conditions, enabling a better understanding of the role of LTBP4 in vivo.

The unique advantage of this product lies in its specificity and reliability, offering robust and reproducible results that enhance experimental validity. Researchers and clinicians choosing LTBP4 Gene Knockout Cell Lines can be assured of high-quality, well-characterized models that ease the exploration of LTBP4 functions and its broader implications in health and disease.

At our company, we pride ourselves on our extensive experience in biotechnological innovations, providing researchers with unrivaled tools to advance their scientific inquiries. Our commitment to excellence ensures that you are equipped with advanced solutions that drive meaningful discoveries in your research endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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