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LSM14A Knockout Cell Lines

Gene: LSM14A

Official Full Name: LSM14A mRNA processing body assembly factorprovided by HGNC

Gene Summary: Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Mar 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO28399 LSM14A Knockout cell line (HeLa) Human LSM14A 1:3~1:6 Negative Online Inquiry
KO28400 LSM14A Knockout cell line (HCT 116) Human LSM14A 1:2~1:4 Negative Online Inquiry
KO28401 LSM14A Knockout cell line (HEK293) Human LSM14A 1:3~1:6 Negative Online Inquiry
KO28402 LSM14A Knockout cell line (A549) Human LSM14A 1:3~1:4 Negative Online Inquiry

Background

LSM14A Gene Knockout Cell Lines are genetically engineered cell lines that have been specifically modified to silence the LSM14A gene, which plays a critical role in RNA metabolism and cellular stress responses. These knockout cell lines provide a powerful tool for researchers looking to investigate the biological functions and regulatory pathways associated with LSM14A, including its involvement in mRNA decay, stress granule formation, and the modulation of gene expression under various physiological conditions.

The primary mechanism of these cell lines is achieved through CRISPR-Cas9 gene editing technology, which allows for precise and efficient disruption of the LSM14A gene sequence. By excising or altering specific portions of the gene, these knockout cell lines enable researchers to create a functional absence of LSM14A, facilitating in-depth studies of its role in cellular processes such as apoptosis, senescence, and response to environmental stressors.

From a scientific standpoint, the LSM14A Gene Knockout Cell Lines are invaluable for a variety of applications, including gene function studies, drug discovery, and the exploration of disease mechanisms. Their use can significantly advance our understanding of several conditions, including cancer and neurodegenerative diseases, where the regulation of RNA and cellular stress responses are disrupted.

What sets these cell lines apart from alternative models is their high specificity and reproducibility, coupled with the inherent stability of CRISPR-generated modifications, ensuring that researchers obtain consistent and reliable results. Additionally, by providing a ready-to-use model, they save time and resources compared to developing custom knockout lines from scratch.

For researchers and clinicians alike, the LSM14A Gene Knockout Cell Lines represent a significant asset, driving forward the study of fundamental biological processes and potentially paving the way for innovative therapeutic strategies. They embody our commitment to delivering high-quality, reliable biological tools that facilitate cutting-edge research. Our company's expertise in genetic engineering and cell biology ensures that these products meet rigorous scientific standards, empowering scientists to accelerate their discoveries in this dynamic field.

Please note that all services are for research use only. Not intended for any clinical use.

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