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LINGO1 Knockout Cell Lines

Gene: LINGO1

Official Full Name: leucine rich repeat and Ig domain containing 1provided by HGNC

Gene Summary: Predicted to enable epidermal growth factor receptor binding activity. Predicted to act upstream of or within negative regulation of oligodendrocyte differentiation; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and neuron development. Predicted to be located in plasma membrane. Predicted to be active in several cellular components, including extracellular space; glutamatergic synapse; and presynapse. Implicated in autosomal recessive intellectual developmental disorder 64 and glaucoma. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO24532 LINGO1 Knockout cell line (HCT 116) Human LINGO1 1:2~1:4 Negative Online Inquiry
KO24533 LINGO1 Knockout cell line (HEK293) Human LINGO1 1:3~1:6 Negative Online Inquiry
KO24534 LINGO1 Knockout cell line (A549) Human LINGO1 1:3~1:4 Negative Online Inquiry

Background

LINGO1 Gene Knockout Cell Lines represent a cutting-edge tool in molecular biology, specifically designed to facilitate research into neurological disorders and cellular signaling pathways. These cell lines have been engineered using CRISPR-Cas9 technology to disrupt the LINGO1 gene, which encodes for a protein that plays a crucial role in neuronal development and myelination. By selectively knocking out this gene, researchers can explore the functional implications of LINGO1 deficiency, providing insights into its involvement in conditions such as multiple sclerosis and other demyelinating diseases.

The key function of LINGO1 Gene Knockout Cell Lines lies in their ability to serve as a precise model for investigating the biochemical signaling pathways affected by the absence of LINGO1. In these cell lines, the mechanisms governing neuronal cell differentiation, growth, and myelin sheath formation can be studied in detail, facilitating a better understanding of their role in neurodegenerative diseases. Researchers can leverage these knockout models to evaluate therapeutic targets, screen potential drugs, and elucidate the pathophysiology of LINGO1-related disorders.

The scientific importance of LINGO1 Gene Knockout Cell Lines is underscored by their broad applications in both academic and clinical research settings. They enable the investigation of gene function and provide a robust platform for exploring possible interventions in diseases where LINGO1 involvement is implicated. More importantly, these cell lines offer an invaluable resource for drug discovery efforts aimed at restoring neuronal function and myelination.

Compared to traditional models, such as wild-type cell lines or animal models, LINGO1 Gene Knockout Cell Lines offer specific advantages: they allow for greater precision in gene manipulation, quicker data acquisition, and reduced variability in experimental outcomes. This enhancement in reliability is crucial for researchers striving to produce reproducible and clinically relevant results.

In summary, LINGO1 Gene Knockout Cell Lines are a powerful resource for researchers and clinicians alike. Their unique design enables advanced studies of gene function and disease mechanisms, paving the way for innovative therapies. Our company, with its commitment to providing high-quality biological products and expertise in genetic engineering, is proud to offer these state-of-the-art cell lines to support the scientific community in unraveling complex biological questions and advancing translational research.

Please note that all services are for research use only. Not intended for any clinical use.

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