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LIMS2 Knockout Cell Lines

Gene: LIMS2

Official Full Name: LIM zinc finger domain containing 2provided by HGNC

Gene Summary: This gene encodes a member of a small family of focal adhesion proteins which interacts with ILK (integrin-linked kinase), a protein which effects protein-protein interactions with the extraceullar matrix. The encoded protein has five LIM domains, each domain forming two zinc fingers, which permit interactions which regulate cell shape and migration. A pseudogene of this gene is located on chromosome 4. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO20763 LIMS2 Knockout cell line (HeLa) Human LIMS2 1:3~1:6 Negative Online Inquiry
KO20764 LIMS2 Knockout cell line (HCT 116) Human LIMS2 1:2~1:4 Negative Online Inquiry
KO20765 LIMS2 Knockout cell line (HEK293) Human LIMS2 1:3~1:6 Negative Online Inquiry
KO20766 LIMS2 Knockout cell line (A549) Human LIMS2 1:3~1:4 Negative Online Inquiry

Background

LIMS2 Gene Knockout Cell Lines are genetically engineered cellular models designed to specifically disrupt the LIMS2 gene, which plays a crucial role in various cellular processes, including cell adhesion, signal transduction, and cytoskeletal dynamics. These cell lines are invaluable for researchers looking to study the functional implications of LIMS2 loss-of-function, providing insights into its involvement in biological pathways and potential implications in diseases such as cancer and fibrosis.

The key functions of the LIMS2 Gene Knockout Cell Lines stem from the precise CRISPR-Cas9 genome editing technology used in their development. By knocking out the LIMS2 gene, these cell lines facilitate the investigation of altered cellular behavior, including proliferation, migration, and differentiation, leading to a deeper understanding of its physiological roles. Researchers can utilize these cell lines to explore how modulating LIMS2 expression influences various signaling pathways, thereby elucidating mechanisms underlying disease processes.

The scientific importance of LIMS2 Gene Knockout Cell Lines extends to both basic research and clinical applications. In basic research settings, they are essential tools for dissecting cellular pathways and identifying novel therapeutic targets. Clinically, they can be used to develop more effective interventions for diseases associated with LIMS2 dysregulation. This capability to bridge basic biology with practical clinical applications makes them a crucial asset for both academic and pharmaceutical research environments.

One of the unique selling points of our LIMS2 Gene Knockout Cell Lines is their high specificity and reliability, which are achieved through advanced genome editing techniques. Unlike traditional knockdown methods that rely on transient expression constructs, these knockout cell lines provide stable and permanent alterations, enabling consistent and reproducible results in experiments. Furthermore, they come with comprehensive documentation and support from our skilled team, ensuring ease of use and integration into existing research workflows.

For researchers and clinicians dedicated to enhancing our understanding of cellular mechanisms and disease pathogenesis, LIMS2 Gene Knockout Cell Lines offer a valuable resource. Their application can significantly advance the field of gene function analysis, aiding in the pursuit of innovative therapeutic strategies.

Our company, known for its commitment to quality and scientific innovation, has developed these cell lines leveraging years of expertise in genetic engineering and cell biology. We are dedicated to providing cutting-edge biological products that empower the scientific community to push the boundaries of knowledge and explore new frontiers in research and medicine.

Please note that all services are for research use only. Not intended for any clinical use.

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