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LIMD1 Knockout Cell Lines

Gene: LIMD1

Official Full Name: LIM domain containing 1provided by HGNC

Gene Summary: Predicted to enable transcription corepressor activity. Involved in several processes, including negative regulation of hippo signaling; negative regulation of macromolecule biosynthetic process; and response to hypoxia. Acts upstream of or within P-body assembly and miRNA-mediated post-transcriptional gene silencing. Located in several cellular components, including P-body; adherens junction; and focal adhesion. Part of RISC complex. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO08615 LIMD1 Knockout cell line (HeLa) Human LIMD1 1:3~1:6 Negative Online Inquiry
KO08616 LIMD1 Knockout cell line (HCT 116) Human LIMD1 1:2~1:4 Negative Online Inquiry
KO08617 LIMD1 Knockout cell line (HEK293) Human LIMD1 1:3~1:6 Negative Online Inquiry
KO08618 LIMD1 Knockout cell line (A549) Human LIMD1 1:3~1:4 Negative Online Inquiry

Background

LIMD1 Gene Knockout Cell Lines are genetically engineered cell models designed to specifically disable the LIM domain-containing protein 1 (LIMD1) gene, thereby providing a valuable tool for studying the biological functions and pathways associated with this protein. The knockout of LIMD1 allows for the analysis of its role in cellular processes such as proliferation, differentiation, and apoptosis, as well as its potential involvement in various diseases, including cancer.

These cell lines utilize CRISPR/Cas9 technology, which enables precise and efficient gene editing through the creation of double-strand breaks in the DNA, followed by the repair processes that can result in the removal of the targeted gene. This mechanism not only ensures a stable knockout of the LIMD1 gene but also provides a reliable model for investigating the downstream effects of its absence in controlled experimental conditions.

The scientific importance of LIMD1 Gene Knockout Cell Lines is underscored by their applications in both basic and applied research. By elucidating the functions of LIMD1, researchers can uncover its role in tumorigenesis and metastasis and gain insights into potential therapeutic targets. Furthermore, these cell lines serve as invaluable resources in drug discovery and development, facilitating the screening of compounds that may interact with pathways influenced by LIMD1 manipulation.

Compared to alternative methods such as RNA interference, the gene knockout approach provided by our cell lines offers a more permanent and unequivocal alteration of gene function, leading to more clear-cut interpretations of phenotypic changes. This permanence eliminates the confounding variables associated with transient gene silencing and allows for long-term studies on cellular behavior and adaptable treatment strategies.

For researchers and clinicians alike, the value of LIMD1 Gene Knockout Cell Lines is evident: they provide the ability to model specific aspects of disease mechanisms with high fidelity. This product stands as an essential addition to any laboratory focused on cancer biology or gene function. Our company prides itself on its expertise in gene editing technologies, and the development of these knockout cell lines aligns with our commitment to advancing research tools that power scientific discovery and innovation.

Please note that all services are for research use only. Not intended for any clinical use.

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