Gene: LIF
Official Full Name: LIF interleukin 6 family cytokineprovided by HGNC
Gene Summary: The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO11231 | LIF Knockout cell line (HeLa) | Human | LIF | 1:3~1:6 | Negative | Online Inquiry |
KO11232 | LIF Knockout cell line (HCT 116) | Human | LIF | 1:2~1:4 | Negative | Online Inquiry |
KO11233 | LIF Knockout cell line (HEK293) | Human | LIF | 1:3~1:6 | Negative | Online Inquiry |
KO11234 | LIF Knockout cell line (A549) | Human | LIF | 1:3~1:4 | Negative | Online Inquiry |
LIF Gene Knockout Cell Lines are a specialized set of genetically engineered cells designed for targeted research in molecular biology and genetics, specifically focusing on the role of the leukemia inhibitory factor (LIF) gene. These cell lines have undergone a process of gene knockout, utilizing CRISPR/Cas9 technology to effectively disrupt the LIF gene. The resultant cells serve as a powerful tool in elucidating the physiological and pathological functions of LIF in various biological processes, including stem cell maintenance, differentiation, and immune responses.
The key mechanism behind the functionality of LIF Gene Knockout Cell Lines lies in their precise gene editing technique, which generates a loss-of-function model for LIF. This contributes to a better understanding of its signaling pathways, particularly in the context of pluripotency and development. Scientists can employ these cell lines in various assays, ranging from gene expression studies to drug testing, facilitating research that reveals how LIF modulation affects cellular and developmental dynamics.
The scientific importance of these cell lines is paramount, particularly in both basic and applied research settings. They enable clinicians and researchers to investigate the implications of LIF in cell signaling, cancer biology, and regenerative medicine. Applications include the exploration of LIF’s influence on stem cell biology, as well as its potential role in neurodegenerative diseases, providing avenues for therapeutic intervention.
What sets LIF Gene Knockout Cell Lines apart from traditional cell lines or alternative knockout models is their specific targeting of the LIF gene combined with the reliability of robust gene editing techniques. These cell lines offer enhanced fidelity and reproducibility in experiments, ensuring that results are both meaningful and reflective of physiological processes.
For researchers and clinicians, the value of these cell lines lies in their capacity to provide insights that propel research forward, contributing to groundbreaking discoveries in gene regulation and cellular function. Investing in LIF Gene Knockout Cell Lines translates to access to advanced models that can streamline the experimental process while delivering high-quality data.
Our company specializes in the development and commercialization of precise genetic tools and bespoke cell lines that are designed with the needs of the research community in mind. With years of expertise in genetic engineering, we are committed to providing products that enhance research capabilities and accelerate scientific discovery.
Please note that all services are for research use only. Not intended for any clinical use.
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