Gene: LHX6
Official Full Name: LIM homeobox 6provided by HGNC
Gene Summary: This gene encodes a member of a large protein family that contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein has tandem LIM domains as well as a DNA-binding homeodomain. The protein functions as a transcription factor involved in embryogenesis and head development and is highly expressed in neural crest derived mesenchyme cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO28107 | LHX6 Knockout cell line (HeLa) | Human | LHX6 | 1:3~1:6 | Negative | Online Inquiry |
KO28108 | LHX6 Knockout cell line (HCT 116) | Human | LHX6 | 1:2~1:4 | Negative | Online Inquiry |
KO28109 | LHX6 Knockout cell line (HEK293) | Human | LHX6 | 1:3~1:6 | Negative | Online Inquiry |
LHX6 Gene Knockout Cell Lines are innovative biological tools designed to facilitate the investigation of LHX6, a member of the LIM homeobox gene family known to play a crucial role in neurogenesis and the development of specific neural circuits. These genetically engineered cell lines are characterized by the inactivation of the LHX6 gene, allowing researchers to explore the gene's functions and contributions to various physiological and pathological processes.
The primary mechanism through which LHX6 gene knockout cell lines operate is the deliberate disruption of the LHX6 gene, leading to the absence of the functional LHX6 protein. This absence enables scientists to elucidate the gene's role in neuronal differentiation, synaptic plasticity, and the potential implications of LHX6 dysregulation in neurodevelopmental disorders such as schizophrenia and autism spectrum disorders. Researchers can employ these cell lines in a variety of assays, including gene expression analysis, protein interactions, and electrophysiological studies, making them essential for translational research in neuroscience.
The scientific importance of these cell lines cannot be overstated. They serve as powerful models for understanding the complexities of neural development and the molecular underpinnings of neurodevelopmental disorders. As a reliable tool for both basic and applied research, LHX6 gene knockout cell lines can significantly advance therapeutic strategies aimed at addressing cognitive dysfunctions associated with LHX6 alterations.
Compared to alternative models, such as wild-type controls or less specific gene knockouts, LHX6 knockout cell lines provide precise insights into the effects of the loss of LHX6 function. Their specificity and targeted nature enhance the validity of experimental results, allowing researchers to make more informed conclusions about gene function and pathogenesis.
For researchers, clinicians, and pharmaceutical developers, LHX6 gene knockout cell lines present an invaluable resource for exploring foundational questions in neurobiology and developing potential interventions. As a leading supplier of advanced biological products, our company is committed to providing high-quality cell lines that empower scientific discovery and innovation in the field of neuroscience, reflecting our dedication to enhancing research capabilities and improving health outcomes.
Please note that all services are for research use only. Not intended for any clinical use.
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