Gene: LHX5
Official Full Name: LIM homeobox 5provided by HGNC
Gene Summary: This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and be involved in the control of differentiation and development of the forebrain. In mice, this protein is essential for the regulation of precursor cell proliferation and the control of neuronal differentiation and migration during hippocampal development. This protein is involved in learning and motor functions in adult mice. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO16555 | LHX5 Knockout cell line (HCT 116) | Human | LHX5 | 1:2~1:4 | Negative | Online Inquiry |
LHX5 Gene Knockout Cell Lines are genetically modified cell lines in which the LHX5 gene has been selectively disrupted or "knocked out." LHX5, a member of the LIM homeobox gene family, plays a critical role in neurodevelopment, particularly in the differentiation and organization of the hypothalamus and other brain regions. These knockout cell lines serve as invaluable tools for studying the consequences of LHX5 deficiency, allowing researchers to elucidate its contributions to neural development and associated physiological processes.
The primary function of LHX5 Gene Knockout Cell Lines lies in their ability to model the specific effects of LHX5 loss. Mechanistically, these cell lines facilitate the investigation of downstream signaling pathways affected by LHX5, such as those involved in neurogenesis and the regulation of hormonal functions. By utilizing gene knockout strategies, scientists can observe variations in cellular behavior and gene expression profiles that provide insights into developmental pathways and potential therapeutic targets.
The scientific importance of LHX5 Gene Knockout Cell Lines extends into both research and clinical settings, where they are instrumental in elucidating genetic interactions and developing novel interventions for brain-related disorders. The understanding gained through these models can pave the way for innovative therapies aimed at treating conditions attributed to the dysregulation of LHX5 and related pathways.
Compared to traditional models, LHX5 Gene Knockout Cell Lines offer distinct advantages including enhanced specificity in studying gene function, the facilitation of high-throughput screening applications, and the ability to generate robust in vitro assays. These features enable researchers to obtain more precise data on the role of LHX5 in pathways implicated in diseases such as obesity, metabolic disorders, and neurodevelopmental syndromes.
For researchers, clinicians, and pharmaceutical developers focused on the intricate dynamics of gene function and disruption, LHX5 Gene Knockout Cell Lines represent a powerful asset in advancing understanding and treatment of complex biological challenges. Our company is committed to providing high-quality, reliable biological products that empower groundbreaking research and contribute to significant advancements in science and medicine.
Please note that all services are for research use only. Not intended for any clinical use.
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