Gene: LGR6
Official Full Name: leucine rich repeat containing G protein-coupled receptor 6provided by HGNC
Gene Summary: This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. The encoded protein is a glycoprotein hormone receptor with a large N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for ligand binding. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO16562 | LGR6 Knockout cell line (HeLa) | Human | LGR6 | 1:3~1:6 | Negative | Online Inquiry |
LGR6 Gene Knockout Cell Lines are a specialized tool in genetic research, designed to specifically delete the LGR6 (leucine-rich repeat-containing G protein-coupled receptor 6) gene from cellular models. These cell lines enable researchers to study gene function, signaling pathways, and the biological roles that LGR6 plays in various physiological and pathological processes. By knocking out this specific gene, scientists can investigate the consequence of its absence on cell behavior, which is crucial for understanding its potential involvement in diseases such as cancer and regenerative disorders.
The primary mechanism of LGR6 Gene Knockout Cell Lines involves the use of CRISPR-Cas9 technology, which allows for precise genome editing. This technique introduces double-strand breaks at the intended locus of the gene, followed by the cell's repair process, which often leads to insertions or deletions that disrupt normal gene function. Consequently, these cell lines serve as valuable platforms for elucidating the biochemical pathways modulated by LGR6, enabling researchers to delineate its role in cell fate decisions, stem cell signaling, and tissue homeostasis.
The scientific importance of these cell lines extends into both research and clinical settings, offering insights into the mechanisms of human diseases and presenting opportunities for the development of therapeutic strategies. Given the role of LGR6 in modulating stem cell activity and its potential implications in tumorigenesis, these knockout models are essential for drug discovery and testing.
One of the key advantages of LGR6 Gene Knockout Cell Lines over traditional knockout models is their precise, targeted nature, which minimizes off-target effects often associated with earlier gene editing techniques. This focus allows for greater confidence in experimental outcomes, providing clarity and reproducibility that are vital for effective scientific inquiry. Additionally, these cell lines can be tailored for specific applications, catering to the needs of a diverse range of research disciplines.
For researchers and clinicians alike, LGR6 Gene Knockout Cell Lines represent a critical asset, enhancing the understanding of gene function within complex biological systems. Our company, with its extensive expertise in genetic engineering and cell line development, is committed to providing high-quality biological products that empower the scientific community in their quest for innovation and discovery.
Please note that all services are for research use only. Not intended for any clinical use.
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