Gene: LETM2
Official Full Name: leucine zipper and EF-hand containing transmembrane protein 2provided by HGNC
Gene Summary: Predicted to enable transmembrane transporter activity. Predicted to be involved in mitochondrial calcium ion transmembrane transport and mitochondrion organization. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO26338 | LETM2 Knockout cell line (HeLa) | Human | LETM2 | 1:3~1:6 | Negative | Online Inquiry |
KO26339 | LETM2 Knockout cell line (HCT 116) | Human | LETM2 | 1:2~1:4 | Negative | Online Inquiry |
KO26340 | LETM2 Knockout cell line (HEK293) | Human | LETM2 | 1:3~1:6 | Negative | Online Inquiry |
KO26341 | LETM2 Knockout cell line (A549) | Human | LETM2 | 1:3~1:4 | Negative | Online Inquiry |
LETM2 Gene Knockout Cell Lines are engineered cells that have undergone precise genetic modification to disrupt the expression of the LETM2 gene, which encodes a protein associated with mitochondrial function and cellular homeostasis. This product provides a vital tool for researchers exploring the gene's role in various biological processes and diseases, including cancer, neurodegeneration, and metabolic disorders.
The primary mechanism of action involves the targeted deletion of the LETM2 gene using advanced gene editing techniques, such as CRISPR/Cas9. By creating a controlled environment devoid of LETM2 protein, researchers can systematically study its function or the pathways it influences. This knockout model allows scientists to observe phenotypic changes in cell viability, proliferation, and metabolic activity that occur in the absence of LETM2, offering insights into its contribution to cellular health and disease progression.
The scientific significance of LETM2 Gene Knockout Cell Lines extends into both basic and translational research. They serve as an invaluable resource for examining mitochondrial dynamics, oxidative stress responses, and potential therapeutic targets in related pathologies. This product can facilitate drug discovery efforts, biomarkers development, and the elucidation of molecular mechanisms underlying complex diseases.
In comparison to alternative models, such as wild-type cells or complete knockout animals, LETM2 Gene Knockout Cell Lines provide a more focused and versatile platform. The ease of culturing these cell lines coupled with the ability to conduct high-throughput assays enhances their applicability in research settings. Furthermore, their specificity allows for clearer interpretation and validation of findings related to the LETM2 gene.
Researchers and clinicians will find LETM2 Gene Knockout Cell Lines exceptionally valuable as they strive to unravel the complexities of gene function in health and disease. Their established utility in research, paired with our company's commitment to high-quality biological products, ensures that you receive reliably engineered tools to advance your scientific inquiries effectively.
Please note that all services are for research use only. Not intended for any clinical use.
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