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LEPROT Knockout Cell Lines

Gene: LEPROT

Official Full Name: leptin receptor overlapping transcriptprovided by HGNC

Gene Summary: LEPROT is associated with the Golgi complex and endosomes and has a role in cell surface expression of growth hormone receptor (GHR; MIM 600946) and leptin receptor (OBR, or LEPR; MIM 601007), thereby altering receptor-mediated cell signaling (Couturier et al., 2007 [PubMed 18042720]; Touvier et al., 2009 [PubMed 19907080]).[supplied by OMIM, Jul 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO20645 LEPROT Knockout cell line (HeLa) Human LEPROT 1:3~1:6 Negative Online Inquiry
KO20646 LEPROT Knockout cell line (HCT 116) Human LEPROT 1:2~1:4 Negative Online Inquiry
KO20647 LEPROT Knockout cell line (HEK293) Human LEPROT 1:3~1:6 Negative Online Inquiry
KO20648 LEPROT Knockout cell line (A549) Human LEPROT 1:3~1:4 Negative Online Inquiry

Background

LEPROT Gene Knockout Cell Lines are specifically engineered cell lines that provide a powerful tool for studying the role of the LEPROT gene in various biological processes and disease states. Utilizing state-of-the-art CRISPR-Cas9 gene-editing technology, these cell lines have been robustly validated to effectively eliminate the expression of the LEPROT gene, allowing researchers to observe the consequent phenotypic and molecular changes.

The principal function of LEPROT Gene Knockout Cell Lines lies in their ability to elucidate gene function and regulatory mechanisms. By disrupting the LEPROT gene, researchers can investigate its impact on cellular pathways, metabolic processes, and interactions with other genes. This can be pivotal in understanding its involvement in conditions such as metabolic disorders and certain cancers, thereby providing insights that could lead to novel therapeutic strategies.

In both research and clinical settings, these knockout cell lines serve as invaluable reagents. They enable the exploration of gene-environment interactions, drug responses, and cellular behavior in a controlled environment, leading to more targeted investigations in gene therapy and precision medicine. The LEPROT knockout models also facilitate high-throughput screening for potential modulators and therapeutic compounds, enhancing drug discovery efforts.

Compared to traditional gene knockdown techniques, LEPROT Gene Knockout Cell Lines offer superior specificity and permanent gene disruption, minimizing off-target effects and allowing for more consistent experimental outcomes. This unique advantage positions them as essential tools for researchers focused on genetics, molecular biology, and pharmacology.

Investing in LEPROT Gene Knockout Cell Lines empowers researchers and clinicians alike to uncover the complexities of gene function and interaction in disease mechanisms. As a company committed to advancing scientific knowledge, we provide these innovative cell lines backed by extensive expertise in genetic engineering and cell biology, ensuring that our clients have access to the tools they need to push the boundaries of their research.

Please note that all services are for research use only. Not intended for any clinical use.

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