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LEMD3 Knockout Cell Lines

Gene: LEMD3

Official Full Name: LEM domain containing 3provided by HGNC

Gene Summary: This locus encodes a LEM domain-containing protein. The encoded protein functions to antagonize transforming growth factor-beta signaling at the inner nuclear membrane. Two transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been associated with osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis.[provided by RefSeq, Nov 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO29061 LEMD3 Knockout cell line (HeLa) Human LEMD3 1:3~1:6 Negative Online Inquiry
KO29062 LEMD3 Knockout cell line (HCT 116) Human LEMD3 1:2~1:4 Negative Online Inquiry
KO29063 LEMD3 Knockout cell line (HEK293) Human LEMD3 1:3~1:6 Negative Online Inquiry
KO29064 LEMD3 Knockout cell line (A549) Human LEMD3 1:3~1:4 Negative Online Inquiry

Background

LEMD3 Gene Knockout Cell Lines are specially engineered cellular models designed to facilitate the study of the LEMD3 gene's role in cellular processes such as nuclear architecture and gene regulation. By employing precise genome editing techniques like CRISPR/Cas9, these cell lines allow researchers to observe the functional impacts of LEMD3 depletion, providing an invaluable tool for elucidating the gene's physiological relevance and involvement in various disease states, including muscular dystrophies and cancers.

The primary mechanism of action associated with the LEMD3 gene involves its crucial role in maintaining nuclear stability and regulating gene expression. By knocking out this gene, researchers can dissect downstream signalling pathways, leading to insights into cellular responses to stress and the potential for oncogenic transformations. This predictive power makes LEMD3 knockout cell lines particularly significant for both basic research and translational studies, unlocking pathways for potential therapeutic interventions.

In contrast to traditional knockdown methods, such as RNA interference, which can have off-target effects and transient activity, the LEMD3 Gene Knockout Cell Lines offer a permanent and precise alteration of the genome. This stability is paramount for long-term studies, providing more robust datasets and replicability. Additionally, these cell lines can be easily cultured and manipulated, enabling high-throughput screening and comprehensive analyses of drug responses or genetic interactions.

Researchers and clinicians seeking reliable models for LEMD3-related studies will find these knockout cell lines to be an essential resource. Their specificity and durability contribute to high-quality research outcomes, aiding in the development of innovative therapies targeting this critical gene.

Our company proudly specializes in delivering cutting-edge biological products such as the LEMD3 Gene Knockout Cell Lines, backed by extensive expertise in genomics and cell biology. We are committed to empowering the scientific community with tools that advance research and inform clinical practices.

Please note that all services are for research use only. Not intended for any clinical use.

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